Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30923245 | 0.92 | TYK2 (0.43) | SYKTYK2JAK1JAK3AXL | |
| SCHEMBL27293243 | 0.92 | TYK2 (0.43) | SYKTYK2JAK1JAK3AXL | |
| SCHEMBL27291200 | 0.92 | SYK (0.47) | SYKTYK2JAK1JAK3 | |
| SCHEMBL30923162 | 0.92 | SYK (0.47) | SYKTYK2JAK1JAK3 | |
| SCHEMBL27417192 | 0.83 | JAK3 (0.49) | SYKTYK2JAK1NPSR1ALOX15 | |
| SCHEMBL27293351 | 0.82 | NPSR1 (0.42) | TYK2JAK1NPSR1ALOX15TSHR | |
| SCHEMBL27293389 | 0.81 | NPSR1 (0.42) | SYKTYK2JAK1NPSR1ALOX15 | |
| SCHEMBL31711666 | 0.80 | TYK2 (0.49) | SYKTYK2JAK1NPSR1ALOX15 | |
| SCHEMBL27293253 | 0.80 | TYK2 (0.49) | SYKTYK2JAK1NPSR1ALOX15 | |
| SCHEMBL27294058 | 0.79 | TYK2 (0.55) | TYK2JAK1NPSR1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |