Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | FRK | P42685 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232479 | 0.82 | MAPT (0.49) | MAPK10MAPK14ALDH1A1SMN1; SMN2MAP4K4 | |
| SCHEMBL27581704 | 0.79 | JAK2 (0.47) | MAPK10MAPK14JAK2MAP4K4EGFR | |
| SCHEMBL27426787 | 0.79 | TYR (0.40) | MAPK10MAPK14MAP4K4EGFRFRK | |
| SCHEMBL30464793 | 0.79 | MAP4K4 (0.49) | MAPK10MAPK14JAK2ALDH1A1MAP4K4 | |
| SCHEMBL3091852 | 0.77 | NPC1 (0.50) | TSHRALDH1A1CYP3A4ALOX15SMN1; SMN2 | |
| SCHEMBL28290775 | 0.76 | EGFR (0.43) | MAPK10MAPK14JAK2TSHRALDH1A1 | |
| SCHEMBL29453704 | 0.76 | JAK2 (0.47) | MAPK10MAPK14JAK2TSHRALDH1A1 | |
| SCHEMBL22719341 | 0.76 | JAK2 (0.47) | MAPK10MAPK14JAK2TSHRALDH1A1 | |
| SCHEMBL27865549 | 0.74 | MAPK14 (0.43) | MAPK10MAPK14JAK2MAP4K4EGFR | |
| SCHEMBL27591971 | 0.74 | ALDH1A1 (0.46) | MAPK10MAPK14ALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1109675-C | Aryl pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2003-05-28 | — | — | CN | disclosed |
| CN-1223641-A | Aryl pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 1999-07-21 | — | — | CN | disclosed |