Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | FRK | P42685 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232479 | 0.82 | MAPT (0.49) | EGFRMAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL5685355 | 0.81 | HSP90AA1 (0.41) | EGFRMAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL27877944 | 0.79 | NPC1 (0.46) | EGFRMAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL7085680 | 0.79 | HSP90AA1 (0.42) | EGFRMAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL13549952 | 0.77 | NPC1 (0.50) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL17292996 | 0.76 | MAPT (0.56) | MAP4K4FRKMAPK9CSNK1A1PRKD3 | |
| SCHEMBL27425865 | 0.76 | MAPK10 (0.47) | EGFRMAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL2650530 | 0.76 | MAP4K4 (0.43) | EGFRMAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL5243501 | 0.76 | NPC1 (0.45) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL16370824 | 0.76 | AAK1 (0.51) | CLK4KDM4EMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110214136-A | Pyrazole derivatives as MALT1 inhibitor | 詹森药业有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-106170489-B | New Pyrazolopyrimidine derivative and its purposes as MALT1 inhibitor | 诺华股份有限公司 | 2019-05-03 | — | — | CN | disclosed |