Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27426751 | 0.94 | ESR1 (0.57) | ESR1ESR2MEN1KMT2AEPHX1 | |
| SCHEMBL5272849 | 0.85 | EPHX1 (0.67) | ESR1ESR2EPHX1CHRM1UBE2N | |
| SCHEMBL3371227 | 0.82 | ESR1 (0.62) | ESR1ESR2MEN1KMT2AEPHX1 | |
| SCHEMBL6049128 | 0.82 | ESR1 (0.83) | ESR1ESR2EPHX1LMNACHRM1 | |
| SCHEMBL3371208 | 0.81 | ESR1 (0.60) | ESR1ESR2EPHX1CHRM1UBE2N | |
| SCHEMBL6958211 | 0.81 | ESR1 (0.60) | ESR1ESR2EPHX1ALDH1A1CHRM1 | |
| SCHEMBL3368827 | 0.77 | ESR1 (0.55) | ESR1ESR2EPHX1CHRM1UBE2N | |
| SCHEMBL27581401 | 0.76 | ESR1 (0.54) | ESR1ESR2MEN1KMT2AEPHX1 | |
| SCHEMBL28980645 | 0.76 | MEN1 (0.49) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL27667714 | 0.76 | ESR1 (0.83) | ESR1ESR2EPHX1LMNACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1214790-C | Medicinal composition for treating inflammation | SEARLE & CO (US) | 2005-08-17 | — | — | CN | disclosed |
| CN-1442139-A | Medicinal composition for treating inflammation | SEARLE & CO (US) | 2003-09-17 | — | — | CN | disclosed |
| CN-1107058-C | Substituted isoxazoles for the treatment of disorders | SEARLE & CO (US) | 2003-04-30 | — | — | CN | disclosed |
| CN-1181075-A | Substituted isoxazoles for the treatment of disorders | SEARLE & CO (US) | 1998-05-06 | — | — | CN | disclosed |