Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11404312 | 0.82 | KDM4E (0.45) | MAPTALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL11438618 | 0.79 | STK17B (0.41) | MAPTALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL9245266 | 0.77 | MAPT (0.38) | MAPTALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL9114881 | 0.75 | CNR1 (0.43) | MAPTALDH1A1KDM4EKMT2ATP53 | |
| SCHEMBL7136989 | 0.73 | PDE3B (0.36) | MAPTALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL7209876 | 0.73 | KDM4E (0.35) | MAPTALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL9123430 | 0.72 | TSHR (0.46) | MAPTALDH1A1CA9HSD17B10L3MBTL1 | |
| SCHEMBL10158281 | 0.70 | MAPT (0.50) | MAPTALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL11386584 | 0.70 | ESR1 (0.47) | CA9 | |
| SCHEMBL8165665 | 0.70 | PDK2 (0.39) | MAPTALDH1A1KDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1128786-C | Process for the manufacture of metoprolol | ASTRA AB (SE) | 2003-11-26 | — | — | CN | disclosed |
| CN-1237958-A | New manufacturing process of metoprolol | ASTRA AB (SE) | 1999-12-08 | — | — | CN | disclosed |