Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11404312 | 0.78 | KDM4E (0.45) | KDM4EMAPTALDH1A1GAACASP1 | |
| SCHEMBL27426795 | 0.73 | MAPT (0.45) | KDM4EMAPTALDH1A1GAACASP1 | |
| SCHEMBL11438618 | 0.71 | STK17B (0.41) | KDM4EMAPTALDH1A1GAACASP1 | |
| SCHEMBL9245266 | 0.69 | MAPT (0.38) | KDM4EMAPTALDH1A1GAACASP1 | |
| SCHEMBL9114881 | 0.68 | CNR1 (0.43) | KDM4EMAPTALDH1A1KMT2ATP53 | |
| SCHEMBL9125315 | 0.67 | ALDH1A1 (0.49) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL8165665 | 0.66 | PDK2 (0.39) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL7136989 | 0.66 | PDE3B (0.36) | KDM4EMAPTALDH1A1GAACASP1 | |
| SCHEMBL10511897 | 0.65 | L3MBTL1 (0.44) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL15146346 | 0.65 | ALDH1A1 (0.41) | KDM4EMAPTALDH1A1GAACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942899-B1 | MANUFACTURING PROCESS OF METOPROLOL | ASTRAZENECA AB (SE) | 2003-03-12 | — | — | EP | disclosed |
| CN-1332844-A | Reaction monitoring | ASTRAZENECA AB (SE) | 2002-01-23 | — | — | CN | disclosed |
| EP-1147401-A1 | REACTION MONITORING | AstraZeneca AB (SE) | 2001-10-24 | — | — | EP | disclosed |
| US-6252113-B1 | O-ETHERIFICATION OF P-(2-METHOXYETHYL)-PHENOL WITH AQUEOUS EPICHLOROHYDRIN, EVAPORATION OF EXCESS EPICHLOROHYDRIN, DISTILLATION, THEN AMINATION WITH ISOPROPYLAMINE TO YIELD METOPROLOL PRODUCT | ASTRAZENECA AB (SE) | 2001-06-26 | — | — | US | disclosed |
| WO-2000040950-A1 | REACTION MONITORING | ASTRAZENECA AB (SE) | 2000-07-13 | — | — | WO | disclosed |
| EP-0942899-A1 | MANUFACTURING PROCESS OF METOPROLOL | Astra Aktiebolag (SE) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998022426-A1 | NEW MANUFACTURING PROCESS OF METOPROLOL | ASTRA AKTIEBOLAG (SE) | 1998-05-28 | — | — | WO | disclosed |