Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27429343 | 1.00 | JAK1 (0.47) | JAK1JAK2TYK2JAK3TLR7 | |
| SCHEMBL27429338 | 0.81 | ADRA2C (0.42) | JAK1JAK2TYK2JAK3TLR7 | |
| Hydrochloric Acid SCHEMBL31361721 | 0.78 | JAK2 (0.40) | JAK1JAK2TYK2JAK3TLR7 | |
| Hydrochloric Acid SCHEMBL31361709 | 0.78 | JAK2 (0.40) | JAK1JAK2TYK2JAK3TLR7 | |
| SCHEMBL6936859 | 0.77 | ALDH1A1 (0.52) | ALDH1A1POLBCYP2D6 | |
| SCHEMBL12093355 | 0.77 | ALDH1A1 (0.52) | ALDH1A1POLBCYP2D6 | |
| SCHEMBL12093440 | 0.77 | ALDH1A1 (0.52) | ALDH1A1POLBCYP2D6 | |
| SCHEMBL24299650 | 0.76 | IRAK4 (0.41) | IRAK4ALDH1A1POLB | |
| SCHEMBL6935094 | 0.76 | ALDH1A1 (0.48) | ALDH1A1POLBCYP2D6 | |
| SCHEMBL12093357 | 0.76 | ALDH1A1 (0.48) | ALDH1A1POLBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024118887-A1 | N-PHENYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXAMIDE DERIVATIVES AS WILD TYPE C-KIT KINASE INHIBITORS FOR THE TREATMENT OF URTICARIA | BLUEPRINT MEDICINES CORPORATION (US) | 2024-06-06 | — | — | WO | disclosed |