Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479104 | 0.75 | NPC1 (0.42) | PTGDR2ALDH1A1NPC1RAB9AGAA | |
| SCHEMBL30496227 | 0.74 | NPC1 (0.38) | PTGDR2ALDH1A1CYP1A2NPC1RAB9A | |
| SCHEMBL1617366 | 0.74 | NPC1 (0.38) | PTGDR2ALDH1A1CYP1A2NPC1RAB9A | |
| SCHEMBL15558301 | 0.70 | ALOX15 (0.60) | ALOX15FGFR1MAPTGAALMNA | |
| SCHEMBL7537504 | 0.69 | L3MBTL1 (0.59) | ALOX15ALDH1A1MAPTGAALMNA | |
| SCHEMBL15547885 | 0.69 | ALOX15 (0.63) | ALOX15GAALMNAHPGDKDM4E | |
| SCHEMBL28428387 | 0.68 | ALOX15 (0.49) | ALOX15ALDH1A1MAPTGAALMNA | |
| SCHEMBL23887393 | 0.67 | ABL1 (0.61) | ALOX15CYP2D6ALDH1A1CYP1A2MAPT | |
| Propionic Acid SCHEMBL10451550 | 0.67 | ALOX15 (0.55) | PTGDR2ALOX15FGFR1MAPTGAA | |
| SCHEMBL5254475 | 0.67 | UGT2B17 (0.38) | ALDH1A1NPC1RAB9ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1105706-C | Cyclic amidino formulations useful as nitric oxide synthase inhibitors | SEARLE & CO (US) | 2003-04-16 | — | — | CN | disclosed |
| CN-1305993-A | Cyclic guanyl preparation used as nitrogen oxide synthetic enzyme inhibitor | SEARLE & CO (US) | 2001-08-01 | — | — | CN | disclosed |
| CN-1189823-A | Cyclic amidino formulations useful as nitric oxide synthase inhibitors | SEARLE & CO (US) | 1998-08-05 | — | — | CN | disclosed |