Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 11/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27480999 | 0.85 | STK4 (0.55) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL27433614 | 0.85 | STK4 (0.55) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL6382054 | 0.84 | STK4 (0.73) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL27460476 | 0.82 | EGFR (0.61) | STK4SRCEGFRERBB2 | |
| SCHEMBL27458919 | 0.77 | STK4 (0.55) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL4742017 | 0.75 | SRC (0.59) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL6382357 | 0.74 | SRC (0.61) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL27482851 | 0.73 | STK4 (0.56) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL4776150 | 0.72 | MAP3K8 (0.47) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL22419654 | 0.71 | STK4 (1.00) | STK4EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1121391-C | Substituted 3-cyano quinolines | AMERICAN CYANAMID CO (US) | 2003-09-17 | — | — | CN | claimed |
| CN-1259125-A | Substituted 3-cyanoquinolines | AMERICAN CYANAMID CO (US) | 2000-07-05 | — | — | CN | claimed |
| CN-1121391-C | Substituted 3-cyano quinolines | AMERICAN CYANAMID CO (US) | 2003-09-17 | — | — | CN | disclosed |