Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.73 |
| ▸ | NPC1 | O15118 | 10/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | ATM | Q13315 | 2/20 | 0.73 |
| ▸ | STAT3 | P40763 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | CASP3 | P42574 | 2/20 | 0.71 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.71 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.71 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.68 |
| ▸ | RELA | Q04206 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27432909 | 0.98 | RAB9A (0.76) | RAB9ASMN1; SMN2NPC1MAPTATM | |
| SCHEMBL27432913 | 0.98 | RAB9A (0.76) | RAB9ASMN1; SMN2NPC1MAPTATM | |
| SCHEMBL27432926 | 0.98 | RAB9A (0.76) | RAB9ASMN1; SMN2NPC1MAPTATM | |
| SCHEMBL27432954 | 0.95 | RAB9A (0.74) | RAB9ASMN1; SMN2NPC1MAPTATM | |
| SCHEMBL9620646 | 0.92 | RAB9A (0.79) | RAB9ASMN1; SMN2NPC1MAPTATM | |
| SCHEMBL10556984 | 0.90 | RAB9A (0.77) | RAB9ASMN1; SMN2NPC1MAPTATM | |
| SCHEMBL9620693 | 0.90 | RAB9A (0.77) | RAB9ASMN1; SMN2NPC1MAPTATM | |
| SCHEMBL10558151 | 0.90 | RAB9A (0.82) | RAB9ASMN1; SMN2NPC1MAPTATM | |
| SCHEMBL10556280 | 0.90 | RAB9A (0.77) | RAB9ASMN1; SMN2NPC1MAPTATM | |
| SCHEMBL9839581 | 0.90 | RAB9A (0.82) | RAB9ASMN1; SMN2NPC1MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12022832-B2 | Compounds and methods for treating nematode infections | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2024-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12022832-B2 | Compounds and methods for treating nematode infections | HNMT, NISCH, HRH2 | RAB9A 2708/4885SMN1; SMN2 1819/4885NPC1 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.