Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | DTYMK | P23919 | 2/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27432394 | 0.85 | NR1H2 (0.45) | CHRM2CHRM4CHRM1CHRM3NR1H2 | |
| SCHEMBL27432029 | 0.84 | NR1H2 (0.44) | CHRM2CHRM4CHRM1CHRM3NR1H2 | |
| SCHEMBL27433186 | 0.83 | KLKB1 (0.38) | CHRM2CHRM4CHRM1CHRM3NR1H2 | |
| SCHEMBL27433294 | 0.81 | MEN1 (0.43) | CHRM2CHRM4CHRM1CHRM3NR1H2 | |
| SCHEMBL31029030 | 0.81 | GRM2 (0.47) | CHRM2CHRM4CHRM1CHRM3HTT | |
| SCHEMBL27432033 | 0.81 | GRM2 (0.43) | CHRM2CHRM4CHRM1CHRM3HTT | |
| SCHEMBL31028998 | 0.81 | GRM2 (0.43) | CHRM2CHRM4CHRM1CHRM3HTT | |
| SCHEMBL27433104 | 0.81 | GRM2 (0.47) | CHRM2CHRM4CHRM1CHRM3HTT | |
| SCHEMBL27433298 | 0.79 | CYP3A4 (0.40) | PARP1CXCR2 | |
| SCHEMBL20139779 | 0.79 | TSHR (0.62) | CHRM2CHRM4CHRM1CHRM3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4638455-A1 | HETEROCYCLIC GLP-1 AGONISTS | Gasherbrum Bio, Inc. (US) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024138048-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024138048-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2024-06-27 | — | — | WO | disclosed |