Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31029003 | 0.86 | TSHR (0.66) | TSHRHTTALDH1A1L3MBTL1POLB | |
| SCHEMBL30138845 | 0.83 | NR1H2 (0.44) | TSHRHTTALDH1A1L3MBTL1POLB | |
| SCHEMBL9968767 | 0.83 | NR1H2 (0.44) | TSHRHTTALDH1A1POLBMAPT | |
| SCHEMBL25419579 | 0.83 | NR1H2 (0.44) | TSHRHTTALDH1A1L3MBTL1POLB | |
| SCHEMBL27432394 | 0.82 | NR1H2 (0.45) | TSHRHTTALDH1A1POLBMAPT | |
| SCHEMBL3436138 | 0.82 | HTT (0.43) | TSHRHTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL31029028 | 0.81 | NR1H2 (0.44) | TSHRHTTPOLBNR1H2MAPK1 | |
| SCHEMBL27432029 | 0.81 | NR1H2 (0.44) | TSHRHTTALDH1A1POLBMAPT | |
| SCHEMBL27432553 | 0.81 | NR1H2 (0.44) | TSHRHTTPOLBNR1H2MAPK1 | |
| SCHEMBL15290072 | 0.81 | GPR119 (0.45) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |