Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.40 |
| ▸ | NOS3 known ✓ | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 known ✓ | P29475 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 5/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroquinone SCHEMBL27257812 | 0.90 | LMNA (0.50) | CA12CA1CA2CA3CA4 | |
| Parachlorophenol SCHEMBL27389089 | 0.88 | MAPK1 (0.47) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL28833788 | 0.87 | TDP1 (0.61) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL5934375 | 0.87 | TDP1 (0.61) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL29392457 | 0.87 | CA12 (0.69) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL11206985 | 0.87 | CA12 (0.69) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL10886697 | 0.87 | CA12 (0.69) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL10433598 | 0.87 | CA12 (0.69) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL478255 | 0.87 | CA12 (0.69) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL9331064 | 0.87 | CA12 (0.69) | TDP1CA12CA1CA2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105765383-A | SALIVARY BIOMARKER FOR CANCER, METHOD AND DEVICE FOR ASSAYING SAME, AND METHOD FOR DETERMINING SALIVARY BIOMARKER FOR CANCER | 唾液科技有限公司 | 2016-07-13 | — | — | CN | claimed |
| CN-101759634-B | Composite method for cefpiramide midbody D-alpha-(4-Hydroxy-6-methylnicotinamido) hydroxyphenylacetic acid | SHANDONG ZHONGCHENG PHARMACEUTICAL CO LTD | 2011-02-16 | — | — | CN | claimed |
| CN-101293868-B | Process for synthesizing D-alpha-(6-methyl-4-hydroxyl nicotinamide base)p-hydroxyphenylacetic acid | QILU ANTIBIOTICS PHARMACEUTICA CO LTD | 2010-11-10 | — | — | CN | claimed |
| CN-101759634-A | Composite method for cefpiramide midbody D-alpha-(4-Hydroxy-6-methylnicotinamido) hydroxyphenylacetic acid | SHANDONG ZHONGCHENG PHARMACEUT | 2010-06-30 | — | — | CN | claimed |
| CN-106574163-B | Temporary bonding adhesive, adhesive layer, wafer processed body, method for manufacturing semiconductor device using same, polyimide copolymer, polyimide hybrid resin, and resin composition | 东丽株式会社 | 2019-12-03 | — | — | CN | disclosed |
| CN-109996646-A | Scaling powder and soldering paste | 千住金属工业株式会社 | 2019-07-09 | — | — | CN | disclosed |
| CN-109746591-A | Scaling powder and soldering paste | 千住金属工业株式会社 | 2019-05-14 | — | — | CN | disclosed |
| CN-108885399-A | Negative light-sensitive resin combination, cured film, the display device and its manufacturing method for having cured film | 东丽株式会社 | 2018-11-23 | — | — | CN | disclosed |
| CN-105492534-B | Polyurethane resin composition, and adhesive composition, laminate, and printed wiring board using same | 东洋纺株式会社 | 2018-09-21 | — | — | CN | disclosed |
| CN-106029744-B | Polyimide resin, resin combination and stacked film using it | 东丽株式会社 | 2018-08-28 | — | — | CN | disclosed |
| CN-108138013-A | Temporary adhesion laminate film uses the substrate processome of temporary adhesion laminate film and the manufacturing method of multilayer board processome and the manufacturing method using their semiconductor devices | 东丽株式会社 | 2018-06-08 | — | — | CN | disclosed |
| CN-104662097-B | Resin combination, cured film, the manufacturing method of laminate film and semiconductor devices | 东丽株式会社 | 2018-06-05 | — | — | CN | disclosed |
| CN-1746255-A | Polishing compound and method for polishing substrate | HITACHI CHEMICAL CO LTD (JP) | 2006-03-15 | — | — | CN | disclosed |
| CN-1646592-A | Unsaturated group-containing multi-branched compound, curable composition containing same, and cured product thereof | TAIYO INK MFG CO LTD (JP) | 2005-07-27 | — | — | CN | disclosed |
| CN-1615295-A | Compounds for the treatment of inflammation, diabetes and related disorders | THERACOS INC (US) | 2005-05-11 | — | — | CN | disclosed |
| CN-1457506-A | Polishing agent and method for polishing substrate | HITACHI CHEMICAL CO LTD (JP) | 2003-11-19 | — | — | CN | disclosed |
| CN-1105724-C | Clavulanic acid extractim process | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | CN | disclosed |
| CN-1258298-A | Process for preparation of metal salt of clavulanic acid | SMITHKLINE BEECHAM PLC (GB) | 2000-06-28 | — | — | CN | disclosed |
| CN-1246875-A | Aqueous binding agent dispersion for cationic electro-dipcoat paint | BASF COATINGS AG (DE) | 2000-03-08 | — | — | CN | disclosed |
| CN-1179161-A | Clavulanic acid extractim process | SMITHKLINE BEECHAM PLC (GB) | 1998-04-15 | — | — | CN | disclosed |