Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GRK2 | P25098 | 3/20 | 0.44 |
| ▸ | GRK3 | P35626 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299458 | 0.82 | HDAC8 (0.63) | HDAC8HDAC6ALDH1A1KMT2AMEN1 | |
| SCHEMBL15819579 | 0.80 | AKR1C3 (0.57) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL12895630 | 0.79 | HDAC8 (0.56) | HDAC8HDAC6ALDH1A1GRK2GRK3 | |
| SCHEMBL27464599 | 0.79 | RAB9A (0.59) | ALDH1A1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL5909363 | 0.79 | HDAC8 (0.83) | HDAC8HDAC6ALDH1A1KMT2AMEN1 | |
| SCHEMBL28617692 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1KCNK3KCNK9 | |
| SCHEMBL13151191 | 0.79 | HDAC8 (0.59) | HDAC8HDAC6ALDH1A1KMT2AMEN1 | |
| SCHEMBL20888372 | 0.79 | HDAC8 (0.59) | HDAC8HDAC6ALDH1A1KMT2AMEN1 | |
| SCHEMBL18193498 | 0.79 | HDAC8 (0.59) | HDAC8HDAC6ALDH1A1KMT2AMEN1 | |
| SCHEMBL26741217 | 0.79 | MEN1 (0.54) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1127479-C | Sulfonylurea derivatives and their use in the control of interleukin-1 activity | PFIZER (US) | 2003-11-12 | — | — | CN | disclosed |
| CN-1245490-A | Sulfonyl urea derivatives and their use in control of interleukin-1 activity | PFIZER (US) | 2000-02-23 | — | — | CN | disclosed |