Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23063858 | 0.70 | CYP11B1 (0.43) | SMN1; SMN2MAPTKDM4EALDH1A1GRM5 | |
| SCHEMBL23817954 | 0.68 | ALDH1A1 (0.50) | CASP2CASP3RAB9ASMN1; SMN2NOTUM | |
| SCHEMBL21107652 | 0.67 | HSD17B10 (0.70) | SMN1; SMN2NOTUMMAPTKDM4EMEN1 | |
| SCHEMBL19126914 | 0.67 | GRM5 (0.49) | MTNR1AMTNR1BGRM5 | |
| SCHEMBL6124247 | 0.66 | IDO1 (0.43) | IDO1MAPTKDM4EALDH1A1POLB | |
| SCHEMBL7240958 | 0.66 | HSD17B10 (0.45) | MTNR1AMTNR1BRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL6073495 | 0.65 | CYP11B2 (0.42) | RAB9ASMN1; SMN2NPC1LMNAPOLB | |
| SCHEMBL4008920 | 0.65 | GRM5 (0.53) | MTNR1AMTNR1BKDM4EMEN1KMT2A | |
| SCHEMBL23063856 | 0.64 | MAPT (0.42) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL1928973 | 0.64 | TSHR (0.75) | CASP3RAB9ASMN1; SMN2NOTUMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024133499-A1 | GLYCINE DERIVATIVES WITH P2X4 RECEPTOR-BLOCKING ACTIVITY AS DIAGNOSTICS AND FOR THE TREATMENT OF PAIN, INFLAMMATION, CANCER, AND OTHER P2X4 RECEPTOR-RELATED DISEASES | RHEINISCHE-FRIEDRICH-WILHELMS-UNIVERSITÄT BONN (DE) | 2024-06-27 | — | — | WO | disclosed |