Sugi Predict

Sugi Predict / Compounds / SCHEMBL2743720

SCHEMBL2743720

SCHEMBL2743720

COCCC(=O)Nc1c(Cl)nc2ccccc2c1CC(C)(C)NS(C)(=O)=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 3/20 0.35
▸ ACSS2 Q9NR19 1/20 0.35
▸ MAPK8 P45983 1/20 0.34
▸ MAPK10 P53779 1/20 0.34
▸ ADAM17 P78536 1/20 0.34
▸ KDM4E B2RXH2 6/20 0.33
▸ MAPT P10636 4/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ MEN1 O00255 4/20 0.33
▸ KMT2A Q03164 4/20 0.33
▸ GLA P06280 3/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ ALDH1A1 P00352 3/20 0.33
▸ USP2 O75604 2/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ ALOX15 P16050 1/20 0.33
▸ APEX1 P27695 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2743823 0.86 GAA (0.36) GAAACSS2MAPK8MAPK10KDM4E
Hydrochloric Acid SCHEMBL2744518 0.84 TOP2A (0.39) GAAKDM4EMAPTSMN1; SMN2LMNA
SCHEMBL6730707 0.75 ACSS2 (0.39) GAAACSS2MAPK8MAPK10KDM4E
SCHEMBL7643118 0.72 MEN1 (0.42) GAAMAPK8MAPK10KDM4EMAPT
Hydrochloric Acid SCHEMBL2744515 0.72 KDM4E (0.33) ADAM17KDM4EMAPTSMN1; SMN2LMNA
SCHEMBL6722290 0.71 TOP2A (0.52) GAAKDM4EMAPTMEN1KMT2A
SCHEMBL843766 0.65 KDM1A (0.39) GAAKDM4ESMN1; SMN2KMT2AGLA
SCHEMBL24808465 0.64 KDM4E (0.49) GAAKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL842241 0.62 EGFR (0.41) GAAKDM4EMAPTSMN1; SMN2LMNA
SCHEMBL1233976 0.62 TLR7 (0.37) GAAKDM4EMAPTLMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8846710-B2 Method of preferentially inducing the biosynthesis of interferon 3M INNOVATIVE PROPERTIES COMPANY (US) 2014-09-30 — — US disclosed
US-8178677-B2 Hydroxyalkyl substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-05-15 — — US disclosed
US-20090029988-A1 Hydroxyalkyl Substituted Imidazoquinolines COLEY PHARMACEUTICAL GROP, INC. (US) 2009-01-29 — — US disclosed
US-20090030031-A1 Method of Preferentially Inducing the Biosynthesis of Interferon COLEY PHARMACEUTICAL GROUP, INC. (US) 2009-01-29 — — US disclosed
EP-1851224-A2 HYDROXYALKYL SUBSTITUTED IMIDAZOQUINOLINES 3M Innovative Properties Company (US) 2007-11-07 — — EP disclosed
WO-2006098852-A2 HYDROXYALKYL SUBSTITUTED IMIDAZOQUINOLINES COLEY PHARMACEUTICAL GROUP, INC. (US) 2006-09-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090030031-A1 Method of Preferentially Inducing the Biosynthesis of Interferon IFNG, IFNAR1, EIF2AK2 GAA 774/4885ACSS2 863/4885MAPK8 3885/4885
US-20090029988-A1 Hydroxyalkyl Substituted Imidazoquinolines IFNG, IRF3, IFNAR1 GAA 804/4885ACSS2 1787/4885MAPK8 4009/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.