⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571226 | 1.00 | — | — | |
| SCHEMBL1571046 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL1570939 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL30457850 | 0.97 | — | — | |
| SCHEMBL24190367 | 0.95 | — | — | |
| SCHEMBL245584 | 0.95 | — | — | |
| SCHEMBL17776508 | 0.77 | — | — | |
| SCHEMBL362734 | 0.72 | ALDH1A1 (0.33) | — | |
| SCHEMBL244154 | 0.72 | ALDH1A1 (0.33) | — | |
| SCHEMBL11100092 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859784-B2 | Stereomerically pure fused bicyclic proline compounds useful for preparing hepatitis C protease inhibitors | CODEXIS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-8574876-B2 | Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds | CODEXIS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20120289709-A1 | Substantially Stereomerically Pure Fused Bicyclic Proline Compounds and Processes for Preparing Boceprevir | CODEXIS, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120244581-A1 | Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds | CODEXIS, INC. (US) | 2012-09-27 | — | — | US | disclosed |
| US-20120130087-A1 | Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors | CODEXIS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-8178333-B2 | Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds | CODEXIS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100063300-A1 | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | CODEXIS, INC. (US) | 2010-03-11 | — | — | US | disclosed |