Sugi Predict

Sugi Predict / Compounds / SCHEMBL2744384

SCHEMBL2744384

SCHEMBL2744384

Cc1ccc(-c2ncn(-c3ccc(O)cc3)n2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 7/20 0.47
▸ KMT2A Q03164 7/20 0.47
▸ MAPT P10636 4/20 0.42
▸ ACHE P22303 1/20 0.42
▸ ALDH1A1 P00352 3/20 0.39
▸ NPC1 O15118 4/20 0.38
▸ RAB9A P51151 4/20 0.38
▸ SMN1; SMN2 Q16637 2/20 0.38
▸ USP2 O75604 1/20 0.38
▸ TP53 P04637 1/20 0.38
▸ PKM P14618 1/20 0.38
▸ NFKB1 P19838 1/20 0.38
▸ NFKB2 Q00653 1/20 0.38
▸ RELA Q04206 1/20 0.38
▸ HPGD P15428 2/20 0.38
▸ ALOX15B O15296 1/20 0.38
▸ CNR1 P21554 1/20 0.36
▸ GPR35 Q9HC97 1/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ MAOA P21397 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21092347 0.92 MEN1 (0.42) MEN1KMT2AMAPTALDH1A1NPC1
SCHEMBL16074561 0.84 AHR (0.44) MEN1KMT2AMAPTALDH1A1NPC1
SCHEMBL17589682 0.84 MAPT (0.42) MEN1KMT2AMAPTALDH1A1NPC1
SCHEMBL6758439 0.84 SMN1; SMN2 (0.48) MEN1KMT2AMAPTACHEALDH1A1
SCHEMBL16089351 0.84 SMN1; SMN2 (0.48) MEN1KMT2AMAPTACHEALDH1A1
SCHEMBL28238356 0.83 ALDH1A1 (0.49) MEN1KMT2AMAPTALDH1A1NPC1
SCHEMBL6758328 0.83 SMN1; SMN2 (0.50) MEN1KMT2AMAPTALDH1A1NPC1
SCHEMBL16074562 0.82 ALDH1A1 (0.51) MEN1KMT2AMAPTACHEALDH1A1
SCHEMBL19244631 0.81 CA12 (0.48) MEN1KMT2AMAPTRAB9AMAOA
SCHEMBL10241058 0.81 MAPT (0.40) MEN1KMT2AMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9732109-B2 Pesticidal compositions DOW AGROSCIENCES LLC (US) 2017-08-15 — — US disclosed
EP-2247603-B1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2016-09-28 — — EP disclosed
EP-2461688-B1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2016-03-16 — — EP disclosed
US-9179681-B2 Pesticidal compositions DOW AGROSCIENCES LLC (US) 2015-11-10 — — US disclosed
EP-2461687-B1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2015-09-16 — — EP disclosed
US-9018363-B2 Pesticidal compositions DOW AGROSCIENCES LLC (US) 2015-04-28 — — US disclosed
US-9006468-B2 Pesticidal compositions DOW AGROSCIENCES, LLC. (US) 2015-04-14 — — US disclosed
US-20150080326-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2015-03-19 — — US disclosed
CN-104356177-A Pesticidal compositions DOW AGROSCIENCES LLC 2015-02-18 — — CN disclosed
US-8927729-B2 Pesticidal compositions DOW AGROSCIENCES, LLC. (US) 2015-01-06 — — US disclosed
US-20120172217-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2012-07-05 — — US disclosed
US-20120172218-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2012-07-05 — — US disclosed
CN-102548411-A Pesticidal compositions DOW AGROSCIENCES LLC 2012-07-04 — — CN disclosed
CN-102548410-A Pesticidal compositions DOW AGROSCIENCES LLC 2012-07-04 — — CN disclosed
US-20120122805-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2012-05-17 — — US disclosed
US-8178658-B2 Insecticide (against arthropods), nematocide; use against pesticide-resistant pests; use on plants and animals; Compounds are tetrahydropyrans substituted with an aryl-heteroaryl-aryl-containing group DOW AGROSCIENCES, LLC (US) 2012-05-15 — — US disclosed
CN-101998963-A Insecticidal composition DOW AGROSCIENCES LLC (US) 2011-03-30 — — CN disclosed
EP-2247603-A1 PESTICIDAL COMPOSITIONS Dow AgroSciences LLC (US) 2010-11-10 — — EP disclosed
WO-2009102736-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2009-08-20 — — WO disclosed
US-20090209476-A1 Insecticide (against arthropods), nematocide; use against pesticide-resistant pests; use on plants and animals; Compounds are tetrahydropyrans substituted with an aryl-heteroaryl-aryl-containing group DOW AGROSCIENCES LLC (US) 2009-08-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090209476-A1 Insecticide (against arthropods), nematocide; use against pesticide-resistant pests; use on plants and animals; Compounds are tetrahydropyrans substituted with an aryl-heteroaryl-aryl-containing group DDT, ACHE, NANP MEN1 4826/4885KMT2A 2528/4885MAPT 2297/4885
US-20120172218-A1 PESTICIDAL COMPOSITIONS ACHE, DDT, PTMS MEN1 3349/4885KMT2A 1970/4885MAPT 3378/4885
US-20150080326-A1 PESTICIDAL COMPOSITIONS ACHE, DDT, PTMS MEN1 3349/4885KMT2A 1970/4885MAPT 3378/4885
US-20120172217-A1 PESTICIDAL COMPOSITIONS DDT, AADAC, ACHE MEN1 3951/4885KMT2A 1101/4885MAPT 2807/4885
US-20120122805-A1 PESTICIDAL COMPOSITIONS ACHE, DDT, PTMS MEN1 3349/4885KMT2A 1970/4885MAPT 3378/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.