Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 5/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3284146 | 0.85 | POLB (0.58) | POLBALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL3018655 | 0.83 | F2 (0.52) | POLBHSD11B1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3026702 | 0.81 | F2 (0.50) | POLBHSD11B1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5974785 | 0.81 | F2 (0.50) | POLBHSD11B1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8078609 | 0.81 | HTT (0.57) | CES2CES1POLBHSD11B1ALOX5 | |
| SCHEMBL27001719 | 0.80 | ALOX5 (0.54) | CES2CES1POLBHSD11B1ALOX5 | |
| SCHEMBL2213274 | 0.79 | RECQL (0.53) | CES2CES1POLBHSD11B1ALDH1A1 | |
| SCHEMBL29046723 | 0.79 | NPC1 (0.51) | POLBHSD11B1LMNAMEN1KMT2A | |
| SCHEMBL28292535 | 0.79 | POLB (0.51) | CES2CES1POLBHSD11B1ALOX5 | |
| SCHEMBL254774 | 0.78 | CES1 (0.70) | CES2CES1POLBALOX5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |