Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.50 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27524630 | 0.84 | KCNH2 (0.58) | MAPK1TSHRKCNH2LOXL2MAOB | |
| SCHEMBL629033 | 0.83 | CRHBP (0.59) | CRHBPCRHR2PYCR1MAPK1TSHR | |
| SCHEMBL27723505 | 0.81 | CYP2D6 (0.56) | PYCR1TSHRMAOBALDH1A1CYP2C19 | |
| SCHEMBL19760403 | 0.81 | CRHBP (0.55) | CRHBPCRHR2PYCR1MAPK1TSHR | |
| SCHEMBL28042132 | 0.79 | CRHBP (0.55) | CRHBPCRHR2PYCR1MAPK1TSHR | |
| SCHEMBL27672402 | 0.77 | ESR1 (0.43) | ALDH1A1 | |
| SCHEMBL27752777 | 0.77 | ALDH1A1 (0.39) | CRHBPCRHR2PYCR1TSHRALDH1A1 | |
| SCHEMBL16682369 | 0.76 | KCNH2 (0.67) | CRHBPCRHR2PYCR1TSHRKCNH2 | |
| SCHEMBL4810294 | 0.76 | CRHBP (0.61) | CRHBPCRHR2PYCR1TSHRKCNH2 | |
| SCHEMBL11542075 | 0.75 | CRHBP (0.68) | CRHBPCRHR2PYCR1TSHRLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1071746-C | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 2001-09-26 | — | — | CN | disclosed |
| CN-1132505-A | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 1996-10-02 | — | — | CN | disclosed |