Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11762846 | 0.91 | ALDH1A1 (0.64) | TSHRALDH1A1ALOX15TDP1LMNA | |
| SCHEMBL9032692 | 0.85 | LMNA (0.63) | TSHRALDH1A1ALOX15CYP3A4NPC1 | |
| SCHEMBL28993877 | 0.84 | ALDH1A1 (0.64) | TSHRALDH1A1ALOX15CYP3A4NPC1 | |
| SCHEMBL7371804 | 0.84 | NPC1 (0.50) | TSHRNPC1L3MBTL1LMNAMAPT | |
| SCHEMBL28171739 | 0.83 | TSHR (0.81) | TSHRALDH1A1ALOX15CYP3A4TDP1 | |
| Ethane SCHEMBL9755027 | 0.82 | LMNA (0.64) | TSHRALDH1A1ALOX15CYP3A4NPC1 | |
| SCHEMBL12141170 | 0.80 | TSHR (0.44) | TSHRALDH1A1CYP3A4LMNAHPGD | |
| SCHEMBL27757401 | 0.77 | ALDH1A1 (0.58) | TSHRALDH1A1CYP3A4NPC1TDP1 | |
| SCHEMBL9400739 | 0.77 | HTT (0.30) | — | |
| SCHEMBL24074018 | 0.76 | HCRTR1 (0.58) | TSHRALDH1A1L3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1134539-C | Thrombopoietin | ��Ĭɭ�����ѧ����˾ | 2004-01-14 | — | — | CN | disclosed |
| CN-1141061-A | Thrombopoietin | GENENTECH INC (US) | 1997-01-22 | — | — | CN | disclosed |