Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 1/20 | 0.72 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | SNCA | P37840 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324249 | 0.84 | CTRC (1.00) | CTRCRAF1NTRK1MAPTAPP | |
| SCHEMBL8318625 | 0.72 | CTRC (0.53) | CTRCRAF1NTRK1MAPTAPP | |
| SCHEMBL5369391 | 0.72 | EGFR (0.41) | CTRCRAF1MAPTERBB2EGFR | |
| SCHEMBL5364237 | 0.71 | ERBB2 (0.47) | CTRCRAF1MAPTERBB2EGFR | |
| SCHEMBL5368044 | 0.71 | SRC (0.50) | NTRK1ERBB2EGFRIGF1RCDK2 | |
| SCHEMBL12694955 | 0.71 | CTRC (0.69) | CTRCRAF1NTRK1MAPTAPP | |
| SCHEMBL12537627 | 0.71 | CTRC (0.69) | CTRCRAF1NTRK1MAPTAPP | |
| SCHEMBL12537625 | 0.71 | CTRC (0.69) | CTRCRAF1NTRK1MAPTAPP | |
| SCHEMBL8325317 | 0.70 | MAPT (0.70) | CTRCRAF1NTRK1MAPTAPP | |
| SCHEMBL8319403 | 0.70 | CTRC (0.52) | CTRCRAF1NTRK1MAPTAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1139929-A | Substituted 3-arylene-7-azaoxindole compounds and methods for their preparation | PHARMACIA SPA (IT) | 1997-01-08 | — | — | CN | disclosed |