Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 1/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.67 |
| ▸ | IGF1R | P08069 | 1/20 | 0.67 |
| ▸ | APP | P05067 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SNCA | P37840 | 2/20 | 0.57 |
| ▸ | EEF2K | O00418 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27463151 | 0.84 | CTRC (0.72) | CTRCERBB2EGFRIGF1RAPP | |
| SCHEMBL12537627 | 0.81 | CTRC (0.69) | CTRCEGFRAPPMAPTSNCA | |
| SCHEMBL12694955 | 0.81 | CTRC (0.69) | CTRCERBB2EGFRIGF1RAPP | |
| SCHEMBL12537625 | 0.81 | CTRC (0.69) | CTRCEGFRAPPMAPTSNCA | |
| SCHEMBL5472251 | 0.80 | ERBB2 (1.00) | CTRCERBB2EGFRIGF1RAPP | |
| SCHEMBL5472252 | 0.80 | ERBB2 (1.00) | CTRCERBB2EGFRIGF1RAPP | |
| SCHEMBL8325317 | 0.78 | MAPT (0.70) | CTRCAPPMAPTSNCARAF1 | |
| SCHEMBL12537515 | 0.77 | CTRC (0.62) | CTRCAPPMAPTSNCAGAA | |
| SCHEMBL12537513 | 0.77 | CTRC (0.62) | CTRCAPPMAPTSNCAGAA | |
| SCHEMBL7318433 | 0.77 | ERBB2 (0.68) | CTRCERBB2EGFRIGF1RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741726-B1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-11-17 | — | — | EP | claimed |
| EP-0741726-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-11-13 | — | — | EP | claimed |
| WO-1996016964-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.P.A (IT) | 1996-06-06 | — | — | WO | claimed |
| EP-0741726-B1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-11-17 | — | — | EP | disclosed |
| US-5719135-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1998-02-17 | — | — | US | disclosed |
| CN-1139929-A | Substituted 3-arylene-7-azaoxindole compounds and methods for their preparation | PHARMACIA SPA (IT) | 1997-01-08 | — | — | CN | disclosed |
| EP-0741726-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-11-13 | — | — | EP | disclosed |
| WO-1996016964-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.P.A (IT) | 1996-06-06 | — | — | WO | disclosed |