Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL27674456 | 0.86 | RECQL (0.42) | HDAC1HDAC2TDP1RECQLKMT2A | |
| Benzophenone SCHEMBL2724412 | 0.81 | ALDH1A1 (0.70) | HDAC1HDAC2CYP3A4MAPTBLM | |
| Benzoic Acid SCHEMBL1573399 | 0.81 | TSHR (0.70) | HDAC1HDAC2CYP3A4MAPTBLM | |
| SCHEMBL7546053 | 0.81 | TSHR (0.47) | HDAC1HDAC2CYP3A4MAPTTDP1 | |
| SCHEMBL27411702 | 0.80 | F2 (0.58) | CYP3A4MAPTBLMTDP1TSHR | |
| SCHEMBL16954 | 0.80 | F2 (0.58) | CYP3A4MAPTBLMTDP1TSHR | |
| Benzoic Acid SCHEMBL2762545 | 0.79 | TSHR (0.67) | HDAC1HDAC2CYP3A4MAPTBLM | |
| Benzamide SCHEMBL2311499 | 0.79 | CYP3A4 (0.76) | HDAC1HDAC2CYP3A4MAPTBLM | |
| Benzophenone SCHEMBL23175180 | 0.78 | ALDH1A1 (0.74) | MAPTTDP1TSHRL3MBTL1CES1 | |
| Thiobenzoic Acid SCHEMBL27656870 | 0.77 | CA12 (0.73) | HDAC1HDAC2CYP3A4MAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1189476-C | Thrombin inhibitors, their preparation and use | BASF AG (DE) | 2005-02-16 | — | — | CN | disclosed |
| CN-1154114-A | New thrombin inhibitors, their preparation and use | BASF AG (DE) | 1997-07-09 | — | — | CN | disclosed |