Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27635032 | 0.80 | LMNA (0.47) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL27796087 | 0.79 | LMNA (0.45) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL27397607 | 0.79 | LMNA (0.45) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL3147962 | 0.77 | ALDH1A1 (0.34) | TSHRLMNAALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL13604014 | 0.76 | LMNA (0.47) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL3506128 | 0.76 | TSHR (0.52) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL13390213 | 0.75 | LMNA (0.45) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL28185568 | 0.75 | KMT2A (0.43) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL11709744 | 0.75 | LMNA (0.41) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL3494816 | 0.71 | LMNA (0.54) | TSHRLMNAF2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066449-C | Tricyclic oxime ethers, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-05-30 | — | — | CN | disclosed |
| CN-1131155-A | Tricyclic oxime ethers, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-09-18 | — | — | CN | disclosed |