SCHEMBL27465614

SCHEMBL27465614

Cc1c(C(=O)O)nc2cc(Cl)ccc2c1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.56
DHODH Q02127 6/20 0.50
DYRK1A Q13627 1/20 0.48
KMT2A Q03164 1/20 0.47
PIM1 P11309 1/20 0.45
PIM2 Q9P1W9 1/20 0.45
POLB P06746 1/20 0.45
EGFR P00533 1/20 0.44
MCL1 Q07820 1/20 0.43
NR4A2 P43354 1/20 0.43
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C8 P10632 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2A6 P11509 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
FABP3 P05413 1/20 0.41
FABP4 P15090 1/20 0.41
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27492843 0.86 KMO (0.58) KMODHODHDYRK1AKMT2APOLB
SCHEMBL3174206 0.85 DHODH (0.64) KMODHODHDYRK1AKMT2APOLB
SCHEMBL5754705 0.83 KMO (0.51) KMODHODHDYRK1AKMT2APIM1
SCHEMBL5755105 0.79 EGFR (0.48) KMODHODHDYRK1AKMT2APIM1
SCHEMBL2908831 0.79 ALDH1A1 (0.62) DHODHDYRK1AKMT2APIM1ALDH1A1
SCHEMBL6603159 0.78 DHODH (0.45) KMODHODHDYRK1AKMT2APIM1
SCHEMBL6080450 0.77 KDM4E (0.51) KMT2APOLBCYP1A2ALDH1A1MAPT
SCHEMBL351868 0.77 ALDH1A1 (0.57) KMODYRK1AKMT2APIM1PIM2
SCHEMBL31372082 0.76 KMO (0.44) KMODHODHDYRK1AKMT2APIM1
SCHEMBL27559336 0.76 EGFR (0.48) KMODHODHDYRK1AKMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1134941-A New pseudopeptides having trifluoromethyl substtuted 2-azazbicyclooctane BAYER AG (DE) 1996-11-06 CN disclosed