Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27482768 | 0.84 | KCNH2 (0.42) | GCKKCNH2 | |
| SCHEMBL27465639 | 0.84 | KCNH2 (0.42) | GCKKCNH2 | |
| SCHEMBL27465641 | 0.84 | KCNH2 (0.42) | GCKKCNH2 | |
| SCHEMBL27482381 | 0.84 | KCNH2 (0.35) | GCKKCNH2KMT2AMEN1 | |
| SCHEMBL2662613 | 0.84 | KCNH2 (0.41) | GCKKCNH2MAPTKMT2AMEN1 | |
| SCHEMBL2645924 | 0.84 | KCNH2 (0.41) | GCKKCNH2MAPTKMT2AMEN1 | |
| SCHEMBL27467644 | 0.84 | SLC6A3 (0.40) | GCKMAPTALDH1A1 | |
| SCHEMBL27482764 | 0.84 | CYP1A2 (0.34) | MAPTKMT2APSMD14MEN1MAPK1 | |
| SCHEMBL27481679 | 0.83 | MAPT (0.36) | MAPTKMT2APSMD14MEN1L3MBTL1 | |
| SCHEMBL2646367 | 0.82 | KCNH2 (0.47) | GCKKCNH2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | claimed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | claimed |
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |