Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 8/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27465639 | 1.00 | KCNH2 (0.42) | KCNH2METAP2METAP1GCKSLC6A3 | |
| SCHEMBL27482751 | 0.90 | KCNH2 (0.41) | KCNH2METAP2METAP1GCKSLC6A3 | |
| SCHEMBL27482768 | 0.88 | KCNH2 (0.42) | KCNH2METAP2METAP1GCKLMNA | |
| SCHEMBL27482381 | 0.88 | KCNH2 (0.35) | KCNH2METAP2METAP1GCKEPHX1 | |
| SCHEMBL2646333 | 0.86 | KCNH2 (0.47) | KCNH2SLC6A3SLC6A2SLC6A4LMNA | |
| SCHEMBL2646335 | 0.86 | KCNH2 (0.47) | KCNH2SLC6A3SLC6A2SLC6A4LMNA | |
| SCHEMBL27483468 | 0.85 | KCNH2 (0.35) | KCNH2METAP2METAP1GCKEPHX2 | |
| SCHEMBL2645000 | 0.85 | SLC6A3 (0.46) | KCNH2METAP2SLC6A3EPHX1EPHX2 | |
| SCHEMBL27465640 | 0.84 | GCK (0.34) | KCNH2GCK | |
| SCHEMBL27466220 | 0.83 | GCK (0.39) | KCNH2METAP2METAP1GCKFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | claimed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | claimed |
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |