Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 3/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.35 |
| ▸ | KMT5C | Q86Y97 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL599817 | 0.88 | LRRK2 (0.44) | COMTPIK3C3LRRK2 | |
| SCHEMBL27461350 | 0.81 | RET (0.35) | COMTPDE4BKMT5BKMT5CIDO1 | |
| SCHEMBL2589369 | 0.77 | DYRK1B (0.40) | DYRK1BRIPK2KCNH2HTR6HTR1A | |
| SCHEMBL12180812 | 0.76 | TXNRD1 (0.38) | COMTLRRK2IDO1MMP2MMP9 | |
| SCHEMBL600488 | 0.76 | RIPK2 (0.50) | PDE4BDYRK1BRIPK2KCNH2 | |
| SCHEMBL2595325 | 0.76 | CA9 (0.50) | — | |
| SCHEMBL17552284 | 0.76 | ALDH1A1 (0.39) | DYRK1BRIPK2KCNH2HTR6HTR1A | |
| SCHEMBL30880575 | 0.76 | RIPK2 (0.50) | PDE4BDYRK1BRIPK2KCNH2 | |
| SCHEMBL27470371 | 0.76 | KDM4E (0.54) | — | |
| SCHEMBL21516999 | 0.75 | TDP1 (0.46) | COMTPDE4BMMP2MMP9GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112854-A1 | INHIBITORS OF RIPK2 AND MEDICAL USES THEREOF | ODYSSEY THERAPEUTICS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |