Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.98 |
| ▸ | MEN1 | O00255 | 4/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | HBB | P68871 | 2/20 | 0.98 |
| ▸ | CASP1 | P29466 | 1/20 | 0.98 |
| ▸ | CASP7 | P55210 | 1/20 | 0.98 |
| ▸ | GLA | P06280 | 3/20 | 0.79 |
| ▸ | TP53 | P04637 | 2/20 | 0.79 |
| ▸ | HPGD | P15428 | 2/20 | 0.79 |
| ▸ | STAT6 | P42226 | 1/20 | 0.79 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.79 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.79 |
| ▸ | GMNN | O75496 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxycamptothecin SCHEMBL28836816 | 1.00 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL9384413 | 0.99 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL25875 | 0.99 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL29929278 | 0.99 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL29350707 | 0.99 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL27638187 | 0.98 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL27905828 | 0.98 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL30872708 | 0.98 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL30426602 | 0.98 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL28094198 | 0.98 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101422156-A | Agriculture bactericide composition and production method and use thereof | UNIV ZHEJIANG FORESTRY (CN) | 2009-05-06 | — | — | CN | claimed |
| CN-101243796-A | Insecticide composition and its processing method | UNIV ZHEJIANG FORESTRY (CN) | 2008-08-20 | — | — | CN | claimed |
| CN-110859818-A | Low-toxicity camptothecin nano-composite and preparation method and application thereof | 河南省生物工程技术研究中心 | 2020-03-06 | — | — | CN | disclosed |
| CN-103432083-A | Preparation process for glycyrrhizic acid-mediated hydroxycamptothecine albumin liver cancer targeting nanoparticle lyophilized powder | UNIV NORTHEAST FORESTRY | 2013-12-11 | — | — | CN | disclosed |
| CN-101654456-B | Water-soluble derivants containing 10-hydroxycamptothecine and preparation method thereof | MEDICAL RES INST CHONGQING UNIVERSITY OF MEDICAL SCIENCES | 2013-01-23 | — | — | CN | disclosed |
| CN-1978448-B | 10-hydroxy camptothecin arginine salt, and its preparing method and use | CHENGDU SANKANG MEDICINE INST | 2010-08-25 | — | — | CN | disclosed |
| CN-100592871-C | Insecticide composition and its processing method | UNIV ZHEJIANG FORESTRY | 2010-03-03 | — | — | CN | disclosed |
| CN-101654456-A | Water-soluble derivants containing 10-hydroxycamptothecine and preparation method thereof | MEDICAL RES INST CHONGQING UNI | 2010-02-24 | — | — | CN | disclosed |
| CN-101601642-A | A kind of vesicle class drug-supplying system and application thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2009-12-16 | — | — | CN | disclosed |
| CN-101422156-A | Agriculture bactericide composition and production method and use thereof | UNIV ZHEJIANG FORESTRY (CN) | 2009-05-06 | — | — | CN | disclosed |
| CN-101243796-A | Insecticide composition and its processing method | UNIV ZHEJIANG FORESTRY (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-1978447-A | 10-hydroxy camptothecin arginine salt, and its preparing method and use | CHENGDU SANKANG MEDICINE INST (CN) | 2007-06-13 | — | — | CN | disclosed |
| CN-1978448-A | 10-hydroxy camptothecin arginine salt, and its preparing method and use | CHENGDU SANKANG MEDICINE INST (CN) | 2007-06-13 | — | — | CN | disclosed |
| CN-1255104-C | Camptothecine and hydroxy camptothecine lipid composition and its preparing method | KANGHAI PHARMACEUTICAL CO LTD (CN) | 2006-05-10 | — | — | CN | disclosed |
| CN-1554344-A | Camptothecine and hydroxy camptothecine lipid composition and its preparing method | 南京康海药业有限公司 | 2004-12-15 | — | — | CN | disclosed |
| CN-1167469-C | Process for preparing nano particles of hydroxycamptothecine polylactate | 黄石李时珍药业集团武汉李时珍药业有 | 2004-09-22 | — | — | CN | disclosed |
| CN-1158079-C | Compound alkyl camptothecine injection prescription and prepn. process thereof | 黄景健 | 2004-07-21 | — | — | CN | disclosed |