Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | HBB | P68871 | 2/20 | 1.00 |
| ▸ | CASP1 | P29466 | 1/20 | 1.00 |
| ▸ | CASP7 | P55210 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 3/20 | 0.80 |
| ▸ | TP53 | P04637 | 2/20 | 0.80 |
| ▸ | HPGD | P15428 | 2/20 | 0.80 |
| ▸ | STAT6 | P42226 | 1/20 | 0.80 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.80 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.80 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.80 |
| ▸ | GMNN | O75496 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxycamptothecin SCHEMBL29350707 | 1.00 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL29929278 | 1.00 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL25875 | 1.00 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL27713853 | 0.99 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL27638187 | 0.99 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL26683387 | 0.99 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL30872708 | 0.99 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL28836816 | 0.99 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL30426602 | 0.99 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL27466705 | 0.99 | TOP1 (0.98) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 289 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111228270-A | Stable controlled release medicine and preparation method thereof | 青岛大学 | 2020-06-05 | — | — | CN | claimed |
| CN-106588946-B | 10-hydroxycamptothecine derivative, synthetic method and its application | 郑州大学 | 2019-01-22 | — | — | CN | claimed |
| CN-108295258-A | A kind of preparation method and applications of 10-hydroxycamptothecine/Porphyrin-Based Sensitizer compound formulation | 哈尔滨工业大学 | 2018-07-20 | — | — | CN | claimed |
| CN-108178803-A | A kind of preparation of cinnamic acid-dextran polymer self-assembled nanometer grain for carrying medicine and its antitumor application thereof | 温州医科大学 | 2018-06-19 | — | — | CN | claimed |
| CN-105412941-B | A kind of pH responsive types carry powder and its preparation method and application | 蚌埠医学院 | 2018-03-13 | — | — | CN | claimed |
| CN-107233577-A | A kind of pH responses and the double medicine-carried nano particles and preparation method of cancer target and application | 清华大学深圳研究生院 | 2017-10-10 | — | — | CN | claimed |
| CN-106967081-A | A kind of synthetic method of the integrated medicine of the diagnosis and treatment with Chemosensitizing effect | 南开大学 | 2017-07-21 | — | — | CN | claimed |
| CN-106806900-A | The preparation and preparation method and application of the pH response release medicines based on 10 HCPTs | 郑州大学 | 2017-06-09 | — | — | CN | claimed |
| CN-104147612-B | Tumor microenvironment specific activated micromolecular targeted conjugate and application thereof | 亚飞（上海）生物医药科技有限公司 | 2017-05-24 | — | — | CN | claimed |
| CN-106620717-A | Amphipathic conjugate anti-tumor nano-drug with function of reversing multidrug resistance of tumors and preparation method and application thereof | 上海交通大学 | 2017-05-10 | — | — | CN | claimed |
| CN-101244272-A | Anti-solid tumors pharmaceutical combination containing topological enzyme inhibitor | SHANDONG LANJIN BIOENGINEERING (CN) | 2008-08-20 | — | — | CN | claimed |
| CN-101066454-A | Solid tumor treating medicine composition | SHANDONG LANJIN BIOENGINEERING (CN) | 2007-11-07 | — | — | CN | claimed |
| CN-1824313-A | Slow release microsphere containing hormone kind anti cancer medicine and its application | JINAN KANGQUAN MEDICINE SCI & (CN) | 2006-08-30 | — | — | CN | claimed |
| CN-1733302-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1686552-A | Anti-solid tumor pharmaceutical composition containing topoisomerase inhibitor | SHANDONG LANJIN BIOLOG ENGINEE (CN) | 2005-10-26 | — | — | CN | claimed |
| CN-1686544-A | Anti entity tumour medicinal composition containing plant alkaloid | SHANDONG LANJIN BIOLOG ENGINEE (CN) | 2005-10-26 | — | — | CN | claimed |
| CN-1686551-A | Anti-solid tumor pharmaceutical composition | SHANDONG LANJIN BIOLOG ENGINEE (CN) | 2005-10-26 | — | — | CN | claimed |
| CN-1679945-A | Anticarcinogen composition | LANJIN BIOLOG ENGINEERING CO L (CN) | 2005-10-12 | — | — | CN | claimed |
| CN-1634585-A | Anti-cancer medicine composition | SHANDONG LANJIN BIOENGINEERING (CN) | 2005-07-06 | — | — | CN | claimed |
| CN-1616099-A | Anti-cancer medicine composition | KONG QINGZHONG (CN) | 2005-05-18 | — | — | CN | claimed |