Hydroxycamptothecin

Hydroxycamptothecin

SCHEMBL29350707

CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(O)ccc3nc2-1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP1 P11387 18/20 1.00
MEN1 O00255 4/20 1.00
KMT2A Q03164 4/20 1.00
SMN1; SMN2 Q16637 4/20 1.00
ALDH1A1 P00352 4/20 1.00
KDM4E B2RXH2 3/20 1.00
CYP3A4 P08684 2/20 1.00
HBB P68871 2/20 1.00
CASP1 P29466 1/20 1.00
CASP7 P55210 1/20 1.00
GLA P06280 3/20 0.80
TP53 P04637 2/20 0.80
HPGD P15428 2/20 0.80
STAT6 P42226 1/20 0.80
CHEK1 O14757 1/20 0.80
HDAC3 O15379 1/20 0.80
ABCC4 O15439 1/20 0.80
GMNN O75496 1/20 0.80
LMNA P02545 1/20 0.80
CYP1A2 P05177 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydroxycamptothecin SCHEMBL9384413 1.00 TOP1 (1.00) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL29929278 1.00 TOP1 (1.00) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL25875 1.00 TOP1 (1.00) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL27713853 0.99 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL27638187 0.99 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL26683387 0.99 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL30872708 0.99 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL28836816 0.99 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL30426602 0.99 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL27466705 0.99 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 496 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026086871-A1 ANTI-AGEING COMPOUNDS, USES THEREFOR, METHOD FOR IDENTIFYING, AND COMPOSITIONS CONTAINING Centre for Translational Stem Cell Biology Limited (CN) 2026-04-30 WO claimed
US-20260120870-A1 ARTIFICIAL INTELLIGENCE-BASED INFORMATION PROVISION METHOD FOR DIAGNOSING LUNG CANCER BY USING BIOMARKER FOR LUNG CANCER DIAGNOSIS AND CLINICAL INFORMATION OF TEST SUBJECT INNOBATION BIO CO LTD (KR) 2026-04-30 US claimed
EP-4687999-A1 TROP2 CONJUGATED BIOLOGICAL MOLECULES, PHARMACEUTICAL COMPOSITIONS AND METHODS OBI Pharma, Inc. (TW) 2026-02-11 EP claimed
US-12493041-B2 Apparatus for diagnosing solid cancers and method for providing information on solid cancer diagnosis INNOBATION BIO CO., LTD. (KR) 2025-12-09 US claimed
EP-4640238-A1 THERAPEUTIC AGENT FOR PULMONARY DISEASE, HEPATIC DISEASE OR RENAL DISEASE, WHICH CONTAINS PGAM-CHK1 BINDING INHIBITOR Kyoto University (JP) 2025-10-29 EP claimed
EP-4597100-A1 ARTIFICIAL INTELLIGENCE-BASED INFORMATION PROVISION METHOD FOR DIAGNOSING LUNG CANCER BY USING BIOMARKER FOR LUNG CANCER DIAGNOSIS AND CLINICAL INFORMATION OF TEST SUBJECT Innobation Bio Co., Ltd. (KR) 2025-08-06 EP claimed
US-20250003952-A1 SENOLYTIC DRUG SCREENING METHOD AND SENOLYTIC DRUG KYOTO UNIVERSITY (JP) 2025-01-02 US claimed
EP-4450070-A1 CRF1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA NEUROCRINE BIOSCIENCES, INC. (US) 2024-10-23 EP claimed
WO-2024206480-A1 TROP2 CONJUGATED BIOLOGICAL MOLECULES, PHARMACEUTICAL COMPOSITIONS AND METHODS O B I PHARMA, INC. (TW) 2024-10-03 WO claimed
CN-118530246-A Synthesis and antitumor application of 10-alkylated 5-spiro camptothecin derivatives 遵义医科大学 2024-08-23 CN claimed
WO-2023091944-A1 COMBINATION THERAPY WITH ANTI-TROP-2 ANTIBODIES AND PARP INHIBITORS THE GENERAL HOSPITAL CORPORATION (US) 2023-05-25 WO claimed
US-20230130925-A1 METHODS TO PREVENT, AMELIORATE AND TREAT COMPLICATIONS FROM VIRAL INFECTIONS ANGELES THERAPEUTICS, INC. 2023-04-27 US claimed
WO-2023038027-A1 SENOLYTIC DRUG SCREENING METHOD AND SENOLYTIC DRUG 国立大学法人京都大学 2023-03-16 WO claimed
CN-108884438-B Method for producing hepatocyte 拜奥拉米那公司 2022-12-23 CN claimed
US-20220349895-A1 APPARATUS FOR DIAGNOSING SOLID CANCERS AND METHOD FOR PROVIDING INFORMATION ON SOLID CANCER DIAGNOSIS INNOBATION BIO CO., LTD. (KR) 2022-11-03 US claimed
WO-2022174058-A1 THIOPHOSPHOPEPTIDES FOR ULTRAFAST TARGETING OF THE GOLGI APPARATUS BRANDEIS UNIVERSITY (US) 2022-08-18 WO claimed
US-20220227700-A1 HDAC3 CATALYTIC INHIBITOR DEVELOPMENT AND USES THEREOF DANA-FARBER CANCER INSTITUTE, INC. 2022-07-21 US claimed
EP-4027139-A2 APPARATUS FOR DIAGNOSING SOLID CANCERS AND METHOD FOR PROVIDING INFORMATION ON SOLID CANCER DIAGNOSIS Innobation Bio Co., Ltd. (KR) 2022-07-13 EP claimed
US-20220193229-A1 NUCLEIC ACID STABILIZING SOLUTION FOR VACCINES, THERAPY, DIAGNOSTICS, STORAGE, AND TRANSPORT Daykin Molecular Systems, LLC 2022-06-23 US claimed
WO-2022120490-A1 CYTOCHROME P450 MONOOXYGENASES AND USES THEREOF THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2022-06-16 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260120870-A1 ARTIFICIAL INTELLIGENCE-BASED INFORMATION PROVISION METHOD FOR DIAGNOSING LUNG CANCER BY USING BIOMARKER FOR LUNG CANCER DIAGNOSIS AND CLINICAL INFORMATION OF TEST SUBJECT KYNU, CPT2, CPT1A TOP1 3385/4885MEN1 1628/4885KMT2A 564/4885
US-20220227700-A1 HDAC3 CATALYTIC INHIBITOR DEVELOPMENT AND USES THEREOF HDAC3, HDAC1, HDAC11 TOP1 3352/4885MEN1 4572/4885KMT2A 113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.