Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 4/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | GABRE | P78334 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1070 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2HCAR2ALDH1A1MAPTCASP7 | |
| Methane SCHEMBL28911261 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2HCAR2ALDH1A1MAPTCASP7 | |
| SCHEMBL27468546 | 0.87 | HCAR2 (0.40) | SMN1; SMN2HCAR2HCAR3ALDH1A1MAPT | |
| SCHEMBL1527741 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTCASP7CASP6 | |
| SCHEMBL902 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2HCAR2HCAR3ALDH1A1MAPT | |
| SCHEMBL4744537 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTCASP7CASP6 | |
| SCHEMBL6365547 | 0.74 | HCAR2 (0.48) | SMN1; SMN2HCAR2HCAR3ALDH1A1MAPT | |
| SCHEMBL27596057 | 0.74 | KDM4C (0.43) | SMN1; SMN2ALDH1A1MAPTCASP7CASP6 | |
| SCHEMBL3830795 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTCASP7CASP6 | |
| SCHEMBL4038271 | 0.73 | MAPT (0.38) | SMN1; SMN2ALDH1A1MAPTCASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1229349-C | Pyridine-3-carboxylic acid derivative | PFIZER (US) | 2005-11-30 | — | — | CN | disclosed |
| CN-1495169-A | Pyridine-3-carboxylic acid derivative | — | 2004-05-12 | — | — | CN | disclosed |
| CN-1134442-C | Pyrazolopyrimidinone cGMP PDE5 inhibitor, preparation method and application thereof and intermediate | �������۸��¼��������������ι�˾ | 2004-01-14 | — | — | CN | disclosed |
| CN-1305478-A | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2001-07-25 | — | — | CN | disclosed |