Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | GPX4 | P36969 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.30 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632512 | 0.91 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTKMT2AMEN1HTT | |
| SCHEMBL3830795 | 0.89 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTKMT2AMEN1HTT | |
| SCHEMBL902 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTGAANPC1ALDH1A1 | |
| SCHEMBL27596057 | 0.83 | KDM4C (0.43) | SMN1; SMN2MAPTKMT2AMEN1HTT | |
| SCHEMBL1070 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTGAAALDH1A1CASP7 | |
| Methane SCHEMBL28911261 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTGAAALDH1A1CASP7 | |
| SCHEMBL18320597 | 0.77 | HTT (0.41) | SMN1; SMN2MAPTKMT2AMEN1HTT | |
| SCHEMBL3960641 | 0.76 | GLA (0.37) | SMN1; SMN2MAPTHTTRAB9APLK1 | |
| SCHEMBL6446674 | 0.76 | CYP1A2 (0.52) | SMN1; SMN2KMT2AMEN1NPC1LMNA | |
| SCHEMBL27468546 | 0.75 | HCAR2 (0.40) | SMN1; SMN2MAPTKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100886-A1 | PREPARATION AND USE OF DEUTERATED UDENAFIL ANALOGUES AS HIGHLY SELECTIVE PDE5 MODULATORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| WO-2003053974-A1 | NOVEL COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-07-03 | — | — | WO | disclosed |
| WO-2001022918-A2 | METHOD OF PREPARATION OF SILDENAFIL | INST FARMACEUTYCZNY (PL) | 2001-04-05 | — | — | WO | disclosed |