Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adapalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB known ✓ | P10826 | 13/20 | 1.00 |
| ▸ | RARG known ✓ | P13631 | 13/20 | 1.00 |
| ▸ | RARA known ✓ | P10276 | 9/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | HSPD1 | P10809 | 1/20 | 1.00 |
| ▸ | GOT1 | P17174 | 1/20 | 1.00 |
| ▸ | GLRA1 | P23415 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | HSPE1 | P61604 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adapalene SCHEMBL29393098 | 1.00 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL26688757 | 1.00 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29688458 | 1.00 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29357372 | 1.00 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29356474 | 1.00 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL4302240 | 1.00 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL9334083 | 0.99 | RARB (0.98) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL642212 | 0.99 | RARB (0.98) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL642210 | 0.99 | RARB (0.98) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL31539457 | 0.99 | RARB (0.98) | RARBRARGRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14856 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260137644-A1 | COMPOSITIONS INCLUDING CAFFEIC ACID PHENETHYL ESTER | XMK THERAPEUTICS INC. (CA) | 2026-05-21 | — | — | US | claimed |
| WO-2026104588-A1 | UROLITHIN COMBINATION | AMAZENTIS SA (CH) | 2026-05-21 | — | — | WO | claimed |
| WO-2025251988-A9 | REAGENT COMBINATION OR KIT FOR CONSTRUCTING EMBRYOID AND USE THEREOF | 广州国家实验室 | 2026-05-15 | — | — | WO | claimed |
| CN-122010697-A | Preparation method of adapalene key intermediate | 江苏联环药业股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-20260125650-A1 | METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES | TRAILHEAD BIOSYSTEMS INC (US) | 2026-05-07 | — | — | US | claimed |
| US-12616710-B2 | Topical compositions | BAUSCH HEALTH IRELAND LIMITED (IE) | 2026-05-05 | — | — | US | claimed |
| US-20260115115-A1 | TYROTHRICIN FOR USE IN THE TREATMENT OR PROPHYLAXIS OF BODY ODOUR AND PREPARATIONS THEREFOR | LEIBBRAND THOMAS (DE) | 2026-04-30 | — | — | US | claimed |
| EP-4727937-A1 | CRYSTALLINE PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPHIC FORM OF THE GLUTAMINYL CYCLASE INHIBITOR VAROGLUTAMSTAT | Vivoryon Therapeutics N.V. (DE) | 2026-04-22 | — | — | EP | claimed |
| US-12600696-B2 | Aromatic compounds | Xeniopro GmbH (DE) | 2026-04-14 | — | — | US | claimed |
| EP-4719373-A1 | PHOTODYNAMIC THERAPY COMBINATIONS FOR IMPROVEMENT OF ACTINIC KERATOSIS, ACNE AND BASAL CELL CARCINOMA | Alexandroff, Anton (GB) | 2026-04-08 | — | — | EP | claimed |
| EP-0409740-B1 | Compound labelled with tritium, its preparation and use, especially in locating retinoid nuclear receptors | CIRD GALDERMA (FR) | 1993-11-03 | — | — | EP | claimed |
| WO-1993015740-A1 | METHODS OF TREATING INFLAMMATORY DERMATOSES | KLIGMAN ALBERT M (US) | 1993-08-19 | — | — | WO | claimed |
| EP-0538283-A1 | SYNTHETIC PEPTIDES AND MIXTURES THEREOF FOR DETECTING HIV ANTIBODIES. | IAF BIOCHEM INT (CA) | 1993-04-28 | — | — | EP | claimed |
| US-5183889-A | For topical or systemic treatment of dermatologic disease, degeneration of conjunction tissues and tumors | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1993-02-02 | — | — | US | claimed |
| US-5149631-A | Compound marked with tritium, its preparation and its use in the location of nuclear receptors of retinoids | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1992-09-22 | — | — | US | claimed |
| US-5073361-A | COMPOUND MARKED WITH TRITIUM, ITS PREPARATION AND ITS USE IN THE LOCATION OF NUCLEAR RECEPTORS OF RETINOIDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA (FR) | 1991-12-17 | — | — | US | claimed |
| US-5019569-A | Topical Administritation of Retinoids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-05-28 | — | — | US | claimed |
| EP-0415766-A2 | Use of retinoids for reversing glucocorticoid-induced skin atrophy | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-03-06 | — | — | EP | claimed |
| US-4940696-A | Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIOUES (CIRD) (FR) | 1990-07-10 | — | — | US | claimed |
| EP-0199636-B1 | BENZONAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN PHARMACY AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1989-02-08 | — | — | EP | claimed |