Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adapalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB known ✓ | P10826 | 13/20 | 0.98 |
| ▸ | RARG known ✓ | P13631 | 13/20 | 0.98 |
| ▸ | RARA known ✓ | P10276 | 9/20 | 0.98 |
| ▸ | MEN1 | O00255 | 3/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.98 |
| ▸ | GOT1 | P17174 | 1/20 | 0.98 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adapalene SCHEMBL29688458 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL2747 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL26688757 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29393098 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29357372 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL4302240 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29356474 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL9334083 | 0.98 | RARB (0.98) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL642212 | 0.98 | RARB (0.98) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL31539457 | 0.98 | RARB (0.98) | RARBRARGRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871972-B2 | Process for the preparation of adapalene and related compounds | JORDI PUIG SERRANO (ZA) | 2014-10-28 | — | — | US | disclosed |
| US-20130030214-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM, S.A. (ES) | 2013-01-31 | — | — | US | disclosed |
| US-8119834-B2 | Process for the preparation of adapalene and related compounds | MEDICHEM, S.A. (ES) | 2012-02-21 | — | — | US | disclosed |
| EP-1902010-B1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM SA (ES) | 2011-11-30 | — | — | EP | disclosed |
| US-20090131713-A1 | Process for the Preparation of Adapalene and Related Compounds | MEDICHEM, S.A. (ES) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131713-A1 | Process for the Preparation of Adapalene and Related Compounds | DHPS, SQLE, CYP51A1 | RARB 8/4885RARG 11/4885RARA 9/4885 |
| US-20130030214-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | DHPS, SQLE, CYP51A1 | RARB 8/4885RARG 11/4885RARA 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.