Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adapalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB known ✓ | P10826 | 13/20 | 0.98 |
| ▸ | RARG known ✓ | P13631 | 13/20 | 0.98 |
| ▸ | RARA known ✓ | P10276 | 9/20 | 0.98 |
| ▸ | MEN1 | O00255 | 3/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.98 |
| ▸ | GOT1 | P17174 | 1/20 | 0.98 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adapalene SCHEMBL26688757 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL4302240 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29688458 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29356474 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29357372 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29393098 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL2747 | 0.99 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL642212 | 0.98 | RARB (0.98) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL642210 | 0.98 | RARB (0.98) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL31539457 | 0.98 | RARB (0.98) | RARBRARGRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE34805-E | Treatment of dermatologic diseases, degeneration of conjunctive tissues; antitumor activity | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1994-12-06 | — | — | US | disclosed |
| US-RE34440-E | Treatment of dermatological diseases and degeneration of conjunctive tissues; antitumor agent | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5212303-A | Benzonaphthalene derivatives, a process for their preparation and their use in therapeutic and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1993-05-18 | — | — | US | disclosed |
| US-5183889-A | For topical or systemic treatment of dermatologic disease, degeneration of conjunction tissues and tumors | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1993-02-02 | — | — | US | disclosed |
| US-5098895-A | Skin disorders and antitumor agents | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1992-03-24 | — | — | US | disclosed |
| US-4940696-A | Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIOUES (CIRD) (FR) | 1990-07-10 | — | — | US | disclosed |
| US-4717720-A | DERMATOLOGIC DISEASES, CONJUCTIVE TISSUE DEGENERATION AND ANTI-TUMOR ACTIVITY | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1988-01-05 | — | — | US | disclosed |