Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 4/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 4/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2746878 | 1.00 | NR1H2 (0.47) | NR1H2KDM1ANOTUMCNR2ESR2 | |
| SCHEMBL29984113 | 1.00 | NR1H2 (0.47) | NR1H2KDM1ANOTUMCNR2ESR2 | |
| SCHEMBL399420 | 0.87 | NR1H2 (0.51) | NR1H2KDM1AESR2BUB1HDAC2 | |
| SCHEMBL17252097 | 0.86 | NR1H2 (0.49) | NR1H2KDM1ANOTUMESR2XIAP | |
| SCHEMBL13734404 | 0.85 | NOTUM (0.41) | NR1H2KDM1ANOTUMCNR2ESR2 | |
| SCHEMBL2306195 | 0.85 | NOTUM (0.43) | NOTUMCNR2XIAPBIRC2BRD4 | |
| SCHEMBL13733409 | 0.84 | XIAP (0.48) | KDM1ANOTUMESR2XIAPBIRC2 | |
| SCHEMBL17252191 | 0.84 | NR1H2 (0.44) | NR1H2KDM1ANOTUMESR2XIAP | |
| SCHEMBL14568588 | 0.83 | NOTUM (0.41) | NOTUMCNR2XIAPBIRC2 | |
| SCHEMBL2559033 | 0.82 | NOTUM (0.39) | NR1H2KDM1ANOTUMCNR2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-20060241115-A1 | Compounds and methods of use | AMGEN INC. | 2006-10-26 | — | — | US | disclosed |
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241115-A1 | Compounds and methods of use | HGF, HGFAC, MET | NR1H2 986/4885KDM1A 4467/4885NOTUM 1151/4885 |
| US-20090176774-A1 | Compounds and methods of use | HGF, HGFAC, MET | NR1H2 986/4885KDM1A 4467/4885NOTUM 1151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.