⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27413768 | 1.00 | — | — | |
| SCHEMBL18933282 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL27834237 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL27511055 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL27852327 | 0.98 | — | — | |
| Methylamine SCHEMBL27752718 | 0.78 | SLC1A3 (0.35) | — | |
| SCHEMBL12897756 | 0.78 | CA2 (0.50) | — | |
| SCHEMBL8284662 | 0.77 | — | — | |
| SCHEMBL8018182 | 0.77 | — | — | |
| SCHEMBL8012127 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105026401-A | Spiro-lactam NMDA receptor modulators and uses thereof | NAUREX INC | 2015-11-04 | — | — | CN | disclosed |
| CN-104812757-A | Crystal of dispiropyrrolidine derivative | DAIICHI SANKYO CO LTD | 2015-07-29 | — | — | CN | disclosed |
| CN-104736569-A | Compounds and methods for enhancing degradation of target proteins and other polypeptides by E3 ubiquitin ligase | UNIV YALE | 2015-06-24 | — | — | CN | disclosed |
| CN-102741257-B | Spiroindolinone pyrrolidines | HOFFMANN LA ROCHE | 2015-03-04 | — | — | CN | disclosed |
| CN-104271554-A | Substituted pyrrolidine-2-carboxamides | HOFFMANN LA ROCHE | 2015-01-07 | — | — | CN | disclosed |
| CN-103635473-A | Disospyrrolidine derivatives | DAIICHI SANKYO CO LTD | 2014-03-12 | — | — | CN | disclosed |
| CN-101541784-B | Hepatitis c virus inhibitors | BRISTOL MYERS SQUIBB CO | 2013-04-24 | — | — | CN | disclosed |
| CN-102741257-A | Spiroindolinone pyrrolidines | HOFFMANN LA ROCHE | 2012-10-17 | — | — | CN | disclosed |
| CN-102612516-A | Substituted pyrrolidine-2-carboxamides | HOFFMANN LA ROCHE | 2012-07-25 | — | — | CN | disclosed |
| CN-102548963-A | Novel N-substituted-pyrrolidines as inhibitors of MDM2-p53 interactions | HOFFMANN LA ROCHE | 2012-07-04 | — | — | CN | disclosed |
| CN-101541784-A | Hepatitis C virus inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2009-09-23 | — | — | CN | disclosed |
| CN-101389737-A | Use of polynuclear phenolic compounds as stabilisers | BASF SE (DE) | 2009-03-18 | — | — | CN | disclosed |
| CN-101341145-A | Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents for the treatment of cancer | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | CN | disclosed |
| CN-1759095-A | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARM INC (US) | 2006-04-12 | — | — | CN | disclosed |
| CN-1205179-C | (P-aminohydroxyphenyl) acrylamide derivatives and coloring agents containing the same | P & G CLAROLL CORP (US) | 2005-06-08 | — | — | CN | disclosed |
| CN-1437578-A | (P-amino-hyaroxyphenyl)-acrylamide derivatives and dyes containing said compounds | WELLA AG (DE) | 2003-08-20 | — | — | CN | disclosed |
| CN-1333766-A | Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds as factor xainhibitors | AVENTIS PHARM PROD INC (US) | 2002-01-30 | — | — | CN | disclosed |
| CN-1172486-A | Proline derivatives useful as inhibitors of human leukocyte elastase | ZENECA LTD (GB) | 1998-02-04 | — | — | CN | disclosed |