SCHEMBL27476555

SCHEMBL27476555

Cc1ccnc(CS)c1C

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 5/20 0.52
NOS3 P29474 4/20 0.52
CCR1 P32246 2/20 0.38
CCR5 P51681 2/20 0.38
CCR8 P51685 2/20 0.38
PSMD14 O00487 1/20 0.34
COPS5 Q92905 1/20 0.34
NOS1 P29475 1/20 0.32
IDO1 P14902 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
GABRA1 P14867 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31
UHRF1 Q96T88 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7124973 0.79 NOS2 (0.48) NOS2NOS3CCR1CCR5CCR8
SCHEMBL660759 0.77 NOS2 (0.46) NOS2NOS3CCR1CCR5CCR8
SCHEMBL2083503 0.77 NOS2 (0.46) NOS2NOS3CCR1CCR5CCR8
SCHEMBL11306368 0.77 NOS2 (0.52) NOS2NOS3CCR1CCR5CCR8
SCHEMBL10714692 0.77 NOS2 (0.46) NOS2NOS3CCR1CCR5CCR8
Hydrochloric Acid SCHEMBL9793478 0.76 NOS2 (0.45) NOS2NOS3CCR1CCR5CCR8
Hydrochloric Acid SCHEMBL16414607 0.76 NOS2 (0.50) NOS2NOS3CCR1CCR5CCR8
SCHEMBL9019314 0.76 NOS2 (0.50) NOS2NOS3CCR1CCR5CCR8
SCHEMBL8469392 0.75 ATP1A1 (0.37) KDM4EGAAMAPT
SCHEMBL9044080 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1102411-A Preparation method of pyridine derivant UNIV SHENYANG PHARMACY (CN) 1995-05-10 CN disclosed