SCHEMBL27477693

SCHEMBL27477693

Br[Hf]Br.[CH]1C=Cc2c1cccc2-c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.36
MAPK1 P28482 1/20 0.36
HSD17B10 Q99714 2/20 0.32
HPGD P15428 1/20 0.32
BCL2L1 Q07817 1/20 0.32
CYP2A6 P11509 1/20 0.32
PTGS2 P35354 1/20 0.31
MGLL Q99685 1/20 0.30
PDCD1 Q15116 1/20 0.30
CD274 Q9NZQ7 1/20 0.30
HNF4A P41235 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26190 0.93 ALDH1A1 (0.37) ALDH1A1MAPK1HSD17B10HPGDBCL2L1
SCHEMBL27463443 0.91 ALDH1A1 (0.35) ALDH1A1MAPK1HSD17B10HPGDBCL2L1
SCHEMBL27462619 0.89 CYP2A6 (0.36) ALDH1A1MAPK1HSD17B10HPGDBCL2L1
SCHEMBL27477267 0.89 ALDH1A1 (0.36) ALDH1A1MAPK1HSD17B10HPGDBCL2L1
SCHEMBL6650232 0.89 PTGS2 (0.36) ALDH1A1MAPK1HSD17B10HPGDBCL2L1
SCHEMBL6537049 0.89 ALDH1A1 (0.30) ALDH1A1MAPK1HSD17B10HPGDBCL2L1
SCHEMBL27463823 0.86 CYP2A6 (0.36) ALDH1A1MAPK1HSD17B10HPGDBCL2L1
SCHEMBL20972417 0.86 CYP2A6 (0.36) ALDH1A1MAPK1HSD17B10HPGDBCL2L1
SCHEMBL6649333 0.85 PTGS2 (0.36) ALDH1A1MAPK1HSD17B10HPGDBCL2L1
SCHEMBL6152668 0.82 ALDH1A1 (0.32) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1160055-A Process for reducing by-product in product mixture HOECHST AG (DE) 1997-09-24 CN disclosed