Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Phenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenol SCHEMBL887189 | 1.00 | CA12 (0.55) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL6009739 | 0.98 | CA12 (0.52) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL8354282 | 0.89 | CA12 (0.69) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL447771 | 0.89 | CA12 (0.69) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL2382227 | 0.89 | CA12 (0.44) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL177595 | 0.88 | CA12 (0.42) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL27571305 | 0.88 | CA12 (0.42) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL27501631 | 0.87 | CA12 (0.65) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL1921716 | 0.87 | CA12 (0.65) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL8718742 | 0.87 | CA12 (0.73) | CA12CA1CA2GLACA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103937877-A | Identification, Assessment, And Therapy Of Cancers With Innate Or Acquired Resistance To Alk Inhibitors | UNIV JICHI MEDICAL | 2014-07-23 | — | — | CN | disclosed |
| CN-1158896-A | Novel stress proteins | HSP KENKYUSHO KK (JP) | 1997-09-10 | — | — | CN | disclosed |