Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PPIB | P23284 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27515104 | 0.80 | MAPT (0.48) | CYP3A4ALDH1A1MAPK1TDP1PHLPP2 | |
| SCHEMBL27774679 | 0.79 | HPGD (0.42) | ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL24522210 | 0.74 | ALDH1A1 (0.46) | CYP3A4ALDH1A1MAPK1TDP1TP53 | |
| SCHEMBL22465856 | 0.74 | ALDH1A1 (0.50) | CYP3A4ALDH1A1MAPK1TDP1TP53 | |
| SCHEMBL7605464 | 0.72 | MAPT (0.44) | CYP3A4ALDH1A1MAPK1TDP1ALOX15 | |
| SCHEMBL3261282 | 0.72 | ALDH1A1 (0.48) | CYP3A4ALDH1A1MAPK1TDP1TP53 | |
| SCHEMBL8993963 | 0.70 | MMP14 (0.38) | CYP3A4ALDH1A1MAPK1TDP1TP53 | |
| SCHEMBL23329003 | 0.70 | GBA1 (0.42) | CYP3A4ALDH1A1MAPK1TDP1TP53 | |
| SCHEMBL16640703 | 0.70 | PHLPP2 (0.37) | CYP3A4ALDH1A1MAPK1TDP1TP53 | |
| SCHEMBL20764319 | 0.69 | CYP3A4 (0.47) | CYP3A4ALDH1A1MAPK1TDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158269-C | 4-aminothiazole derivs, their preparation and their use as inhibitors of cyclin-dependent kinases | ������ҩ������˾ | 2004-07-21 | — | — | CN | disclosed |
| CN-1276789-A | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin dependent kinases | AGOURON PHARMA (US) | 2000-12-13 | — | — | CN | disclosed |