Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.95 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.91 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.91 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.91 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.91 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.91 |
| ▸ | HTR1A | P08908 | 2/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.91 |
| ▸ | PGR | P06401 | 1/20 | 0.91 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.91 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.91 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.91 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.91 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.91 |
| ▸ | GALR3 | O60755 | 2/20 | 0.86 |
| ▸ | GAA | P10253 | 1/20 | 0.86 |
| ▸ | RAB9A | P51151 | 1/20 | 0.86 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL28135641 | 0.98 | CHRM1 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL40885 | 0.98 | CHRM5 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL27920125 | 0.98 | CHRM5 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL27591882 | 0.95 | CHRM5 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL3753925 | 0.95 | CHRM5 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL5468500 | 0.95 | CHRM5 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL31072232 | 0.95 | CHRM5 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL3216 | 0.95 | CHRM1 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL2518957 | 0.95 | CHRM1 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL9303735 | 0.93 | CHRM1 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114540482-B | Analysis device and method for improving atrial flutter myocardial fibrosis by astragalus-perot pulse composition based on space transcriptome technology | 中国中医科学院广安门医院 | 2024-07-16 | — | — | CN | disclosed |
| CN-116897885-B | Method for constructing atrial fibrillation small animal model and application thereof | 中国医学科学院阜外医院 | 2023-12-08 | — | — | CN | disclosed |
| CN-114948944-B | Application of composition containing sulbactam sodium sulfate and amiodarone in preparation of drugs for treating arrhythmia | 扬州中宝药业股份有限公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-116897885-A | Method for constructing atrial fibrillation small animal model and application thereof | 中国医学科学院阜外医院 | 2023-10-20 | — | — | CN | disclosed |
| CN-114948944-A | Application of composition containing sulcardine sulfate and amiodarone in preparation of medicine for treating arrhythmia | 扬州中宝药业股份有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-114540482-A | Analysis device and method for improving atrial fibrillation myocardial fibrosis by Qibo pulse-activating composition based on space transcriptome technology | 中国中医科学院广安门医院 | 2022-05-27 | — | — | CN | disclosed |
| CN-114388066-A | Analysis device and method for atrial fibrillation myocardial fibrosis | 中国中医科学院广安门医院 | 2022-04-22 | — | — | CN | disclosed |
| CN-108939052-B | Application of exenatide in preparation of medicine for preventing or treating atrial fibrillation | 江苏省中医药研究院 | 2021-03-16 | — | — | CN | disclosed |
| CN-108939052-A | Purposes of the Exenatide in the drug of preparation prevention or treatment atrial fibrillation | 江苏省中医药研究院 | 2018-12-07 | — | — | CN | disclosed |
| CN-108478703-A | A kind of Chinese medicine composition and quality determining method for treating arrhythmia cordis | 辽宁中医药大学 | 2018-09-04 | — | — | CN | disclosed |
| CN-101422562-A | Medicine for treating premature beat and atrial fibrillation | TEACHING HOSPITAL OF LIAONING (CN) | 2009-05-06 | — | — | CN | disclosed |
| CN-1156024-A | Antiarrhythmic containing isoliquirtin | NANJING TRADITIONAL CHINESE ME (CN) | 1997-08-06 | — | — | CN | disclosed |