Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | FADS1 | O60427 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL6034251 | 1.00 | MEN1 (0.51) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL10310181 | 0.89 | MEN1 (0.62) | MEN1KMT2AMAPTHTTALDH1A1 | |
| Nitric Acid SCHEMBL4467542 | 0.86 | RAB9A (0.44) | MEN1KMT2AMAPTHTTALDH1A1 | |
| Nitric Acid SCHEMBL4490937 | 0.86 | EPHX1 (0.51) | MEN1KMT2AMAPTHTTALDH1A1 | |
| Nitric Acid SCHEMBL4467551 | 0.86 | RAB9A (0.44) | MEN1KMT2AMAPTHTTALDH1A1 | |
| Nitric Acid SCHEMBL3859433 | 0.82 | LMNA (0.58) | MEN1KMT2AMAPTHTTALDH1A1 | |
| Nitric Acid SCHEMBL2544082 | 0.81 | NPC1 (0.53) | MEN1KMT2AMAPTHTTALDH1A1 | |
| Nitric Acid SCHEMBL6034740 | 0.80 | AR (0.47) | HTTALDH1A1TSHRLMNASMN1; SMN2 | |
| Nitric Acid SCHEMBL6034732 | 0.80 | AR (0.47) | HTTALDH1A1TSHRLMNASMN1; SMN2 | |
| Nitric Acid SCHEMBL6034482 | 0.79 | NPC1 (0.53) | MEN1KMT2AMAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1168721-C | 5-cyano-2-aminopyrimidine derivatives | О | 2004-09-29 | — | — | CN | disclosed |
| CN-1370152-A | 5-cyano-2-aminopyrimidine derivatives | CELLETECH CHIROSCIENCE LTD (GB) | 2002-09-18 | — | — | CN | disclosed |