Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.64 |
| ▸ | FLT3 | P36888 | 5/20 | 0.63 |
| ▸ | MET | P08581 | 15/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | INSR | P06213 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | CSF1R | P07333 | 2/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.59 |
| ▸ | TEK | Q02763 | 2/20 | 0.59 |
| ▸ | MST1R | Q04912 | 2/20 | 0.59 |
| ▸ | BTK | Q06187 | 2/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | CHUK | O15111 | 1/20 | 0.59 |
| ▸ | MUSK | O15146 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548967 | 0.93 | AXL (0.65) | AXLFLT3METKDRINSR | |
| SCHEMBL2747111 | 0.88 | KDR (0.75) | AXLFLT3METKDRINSR | |
| SCHEMBL4549007 | 0.88 | FLT3 (0.75) | AXLFLT3METKDRINSR | |
| SCHEMBL4549008 | 0.87 | KDR (0.65) | AXLFLT3METKDRINSR | |
| SCHEMBL2748792 | 0.85 | KDR (0.60) | AXLFLT3METKDRAURKA | |
| SCHEMBL4548851 | 0.85 | FLT3 (0.71) | AXLFLT3METKDRINSR | |
| SCHEMBL2748848 | 0.84 | KDR (0.70) | METKDRAURKALCKTEK | |
| SCHEMBL2747696 | 0.82 | MET (0.67) | AXLFLT3METKDRINSR | |
| SCHEMBL3921794 | 0.82 | AXL (0.65) | AXLFLT3METKDRINSR | |
| SCHEMBL2747460 | 0.81 | AXL (0.80) | AXLFLT3METKDRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-20060241115-A1 | Compounds and methods of use | AMGEN INC. | 2006-10-26 | — | — | US | disclosed |
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241115-A1 | Compounds and methods of use | HGF, HGFAC, MET | AXL 1107/4885FLT3 56/4885MET 3/4885 |
| US-20090176774-A1 | Compounds and methods of use | HGF, HGFAC, MET | AXL 1107/4885FLT3 56/4885MET 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.