Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | CTSC | P53634 | 2/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL5315679 | 0.90 | KDM4E (0.63) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL4295680 | 0.88 | KDM4E (0.59) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL18614910 | 0.87 | KDM4E (0.52) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL18614911 | 0.87 | KDM4E (0.52) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL4290188 | 0.86 | KMT2A (0.53) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7267888 | 0.86 | KDM4E (0.63) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL8831012 | 0.85 | PTH1R (0.41) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL2060360 | 0.85 | KDM4E (0.76) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28697957 | 0.85 | KDM4E (0.76) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL4400705 | 0.85 | KDM4E (0.76) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151761-A | Subtilisin BPN' variants with reduced adsorption and increased hydrolysis | PROCTER & GAMBLE (US) | 1997-06-11 | — | — | CN | disclosed |