Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | GHSR | Q92847 | 4/20 | 0.44 |
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | MC5R | P33032 | 2/20 | 0.44 |
| ▸ | MC3R | P41968 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL18614911 | 1.00 | KDM4E (0.52) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27687187 | 0.91 | KDM4E (0.63) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL5315679 | 0.91 | KDM4E (0.63) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL9617704 | 0.91 | KDM4E (0.63) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL4295680 | 0.88 | KDM4E (0.59) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27657715 | 0.87 | KDM4E (0.52) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL4290188 | 0.87 | KMT2A (0.53) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27483196 | 0.87 | KDM4E (0.55) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28548179 | 0.86 | KDM4E (0.46) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28880639 | 0.86 | KDM4E (0.45) | KDM4EMAPTMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294827-A1 | PARAOXONASE FUSION POLYPEPTIDES AND RELATED COMPOSITIONS AND METHODS | Theripion, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3328881-A1 | APOA-1 FUSION POLYPEPTIDES AND RELATED COMPOSITIONS AND METHODS | Theripion, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |
| WO-2017044424-A1 | APOA-1 FUSION POLYPEPTIDES AND RELATED COMPOSITIONS AND METHODS | THERIPION, INC. (US) | 2017-03-16 | — | — | WO | disclosed |