Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2748906 | 0.91 | PRKD3 (0.62) | PRKD3PRKD1PRKD2CHEK2MAP4K4 | |
| SCHEMBL2750950 | 0.86 | CHEK2 (0.56) | CHEK2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2750714 | 0.83 | CHEK2 (0.55) | CHEK2GAAKMT2AMAP4K4RAB9A | |
| SCHEMBL2750800 | 0.83 | PRKD3 (0.54) | PRKD3PRKD1PRKD2GAAKMT2A | |
| SCHEMBL2750178 | 0.81 | FYN (0.55) | CHEK2KMT2AMAP4K4RAB9AKDM4E | |
| SCHEMBL2749378 | 0.81 | MAP4K4 (0.65) | CHEK2GAAKMT2AMAP4K4RAB9A | |
| SCHEMBL2748862 | 0.81 | ALDH1A1 (0.57) | CYP1A2CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL2747954 | 0.81 | MAP4K4 (0.50) | CHEK2KMT2AMAP4K4RAB9AKDM4E | |
| SCHEMBL2748144 | 0.81 | CHEK2 (0.62) | CHEK2KMT2AMAP4K4RAB9AFYN | |
| SCHEMBL2748403 | 0.81 | MAP4K4 (0.47) | CHEK2GAAKMT2AMAP4K4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178668-B2 | 2-aminopyridine kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090197862-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197862-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | ERBB2, ABL2, TIE1 | PRKD3 199/4885PRKD1 117/4885PRKD2 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.