SCHEMBL2748415

SCHEMBL2748415

FC(F)(F)c1ccc(C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.78
ALDH1A1 P00352 1/20 0.78
KIF11 P52732 5/20 0.64
TRPV6 Q9H1D0 2/20 0.52
CYP19A1 P11511 1/20 0.48
BACE1 P56817 1/20 0.47
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
OPRM1 P35372 1/20 0.44
OPRL1 P41146 1/20 0.44
ACP3 P15309 1/20 0.44
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
ORAI1 Q96D31 1/20 0.42
ORAI2 Q96SN7 1/20 0.42
ORAI3 Q9BRQ5 1/20 0.42
MGLL Q99685 1/20 0.42
SRD5A2 P31213 1/20 0.41
CYP1A1 P04798 1/20 0.41
MAOB P27338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoromethylbenzene SCHEMBL27760126 0.88 TSHR (1.00) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL8692 0.88 TSHR (1.00) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL175647 0.88 TSHR (1.00) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL7870246 0.85 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL14121438 0.85 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL9482280 0.85 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL30957761 0.85 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL1830622 0.85 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL22806921 0.85 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL14121761 0.85 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8268865-B2 Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof REMPEX PHARMACEUTICALS, INC. (US) 2012-09-18 US disclosed
US-20120165276-A1 QUATERNARY ALKYL AMMONIUM BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF MPEX PHARMACEUTICALS, INC. (US) 2012-06-28 US disclosed
US-8178490-B2 Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof REMPEX PHARMACEUTICALS, INC. (US) 2012-05-15 US disclosed
US-20100152098-A1 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF MPEX PHARMACEUTICALS, INC. (US) 2010-06-17 US disclosed
WO-2010054102-A2 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF MPEX PHARMACEUTICALS, INC. (US) 2010-05-14 WO disclosed
EP-2155775-A2 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF Mpex Pharmaceuticals, Inc. (US) 2010-02-24 EP disclosed
EP-2155776-A2 QUATERNARY ALKYL AMMONIUM BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF Mpex Pharmaceuticals, Inc. (US) 2010-02-24 EP disclosed
US-20080318957-A1 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF MPEX PHARMACEUTICALS, INC. (US) 2008-12-25 US disclosed
WO-2008141012-A2 QUATERNARY ALKYL AMMONIUM BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF MPEX PHARMACEUTICALS, INC. (US) 2008-11-20 WO disclosed
WO-2008141010-A2 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF MPEX PHARMACEUTICALS, INC. (US) 2008-11-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100152098-A1 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF ABCB11, ABCB1, SLC47A1 TSHR 4679/4885ALDH1A1 4062/4885KIF11 4467/4885
US-20080318957-A1 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF ABCB11, ABCB1, SLC47A1 TSHR 4679/4885ALDH1A1 4062/4885KIF11 4467/4885
US-20120165276-A1 QUATERNARY ALKYL AMMONIUM BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF ABCB11, ABCC1, SLC47A1 TSHR 4138/4885ALDH1A1 3299/4885KIF11 4292/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.